DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rpk and Asic5

DIOPT Version :9

Sequence 1:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_067345.1	Gene:	Asic5 / 58170	MGIID:	1929259	Length:	495	Species:	Mus musculus

Alignment Length:	566	Identity:	130/566 - (22%)
Similarity:	210/566 - (37%)	Gaps:	177/566 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 EYCRNTSIHGVQYLGEQERPFRERIFWLFVFLISIYGCSTLIQSAYTK------W-TETPVIVSF 95
            ::..:||.||:..:.:.:...| ::.||.|.|.|:   |.|:...|::      | |.|.:.|.:
Mouse    40 DFAMSTSFHGIHNIAQNQNKVR-KVIWLAVVLGSV---SLLVWQIYSRLVNYFTWPTTTSIEVQY 100

  Fly    96 AEKSTPVWNIPFPAVTVCS----ETKRVLKQKGKETTYADLYSQFSEDMRASRVFRPENVSALEM 156
            .||      |.|||||:|:    :|:.|       :.:..::  |..|: .|:|.|.:.:||...
Mouse   101 VEK------IEFPAVTLCNLNRFQTEAV-------SRFGIIF--FLWDI-VSKVLRLQEISANNT 149

  Fly   157 EEFRTLLHVCN------TQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRYFFYCRWLSRFGECETF 215
            ....||..|.|      |:.::.:...:..|.|.:                          ||.|
Mouse   150 GSPETLDFVTNHQNFSITEFVKNNGFYLNNDTLVH--------------------------CEFF 188

  Fly   216 --------FRKTLTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLETGYAL 272
                    |:...||.|.|:|||              |.        |||.:::.......|..|
Mouse   189 GKTCSPKDFKHVFTEYGNCFTFN--------------YG--------ENIQNKNKVSVSGRGLKL 231

  Fly   273 DSDV--ETFPARVLSAGARSGIFLALQSFKQEVDYACRGPVQGFKVGKFENVLLHAPDDVPQVSK 335
            ..||  |.|....:...|.:|:...:.|.|:|..:      .|  :|....|.:||...:.|:..
Mouse   232 LLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQF------DG--LGLSSPVGMHARVTIRQLKT 288

  Fly   336 QFVRIPMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFLSHERSLRFFKVYTESNCQLECLANFTL 400
            .....|.|:     ..||:                       .||.|..|:...|..||.|....
Mouse   289 VHQEYPWGE-----CNPNI-----------------------KLRNFITYSTYGCLKECKARHIQ 325

  Fly   401 TKCGCVKFSMPRN-VDMPVCGEDKIHCY-------DRAERELLVREFKRVKALNAGRENSRSVES 457
            ..|||:.|.:|.| |:   |  |.:..|       |..||:.|         ...|..||
Mouse   326 RLCGCLPFLLPGNGVE---C--DLLEYYNCVSPILDHIERKGL---------CTMGTHNS----- 371

  Fly   458 ACNCMPACTSLVYNTEISQANFDLEEMLVAEGDTEFL-------KEYPGSQMSRLSIYFKQSQFI 515
              :|..:|....|...:|.:.|.      ::..|.||       :||....:..:.|.:....:.
Mouse   372 --SCPVSCEETEYPATVSYSTFP------SQRATRFLAKKLNQSQEYIRENLVNIEINYSDLNYK 428

  Fly   516 TSKRSELYGMTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRLFTN 561
            .:::.:...:.|.||:.||..|||.|.|:::::|:|.:|    |||
Mouse   429 ITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYF----FTN 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:279230	125/554 (23%)
Asic5	NP_067345.1	ASC	41..466	CDD:366339	126/555 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837898
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I5086
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.700