Protein Alignment rpk and ASIC4

DIOPT Version :10

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_054198812.1
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 666
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 116/561 - (20%)
• Similarity: 194/561 - (34%)
• Gaps: 163/561 - (29%)

  Fly    39 YCRNTSIHGV-QYLGEQERPFRERIFWLFVFLIS----IYGCSTLIQSAYTKWTETPVIVSFAEK 98
            :...:::||: :..|......| |..|....|.|    :|..:.|.:...|:    |.:|:. :.
Human   172 FASTSTLHGLGRACGPGPHGLR-RTLWALALLTSLAAFLYQAAGLARGYLTR----PHLVAM-DP 230

  Fly    99 STPVWNIPFPAVTVCSETKRVLKQKGKETTYADLYSQFSEDMRASRVFRPENVSALEMEEFRTLL 163
            :.|.....|||||:|:..:                            ||...:|..:      :.
Human   231 AAPAPVAGFPAVTLCNINR----------------------------FRHSALSDAD------IF 261

  Fly   164 HVCNTQII---EEDIPLIAG---DDLDYFDVLQRMLPQFDRYFFYCRWLSRFGECE-TFFRKTLT 221
            |:.|...:   :.|....||   .:.|..|:|.|...|.......|.:...  .|. :.|....|
Human   262 HLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLADMLKSCNFSGH--HCSASNFSVVYT 324

  Fly   222 EEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLETGYALDSDVETFPARVLSA 286
            ..|.|||||                  .:|.                        .:.|:|  :.
Human   325 RYGKCYTFN------------------ADPR------------------------SSLPSR--AG 345

  Fly   287 GARSGIFLALQSFKQEVDYACRGPV------QGFKVGKFENVLLHAPDDVPQVSKQFVRIPMGKE 345
            |..||:.:.|..  |:.:|.   |:      ..|:.|  ..|.:|:.::.|.:.:....:..|.:
Human   346 GMGSGLEIMLDI--QQEEYL---PIWRETNETSFEAG--IRVQIHSQEEPPYIHQLGFGVSPGFQ 403

  Fly   346 VLIAVKPNMITMSSGIAEYHP-----VRRQCFLSHERSLRFFKVYTESNCQLECLANFTLTKCGC 405
            ..::.:...:|       |.|     .|.:..| .|..|:.:..|:.|.|:|.|.....|.:|.|
Human   404 TFVSCQEQRLT-------YLPQPWGNCRAESEL-REPELQGYSAYSVSACRLRCEKEAVLQRCHC 460

  Fly   406 VKFSMPRNVDMPVCGED-KIHCYDRAERELLVREFKRVKALNAGRENSRSVESACNCMPACTSLV 469
            ....||.|  ..:|..: .|.|.|..           :.:|..|      .|..|.|...|....
Human   461 RMVHMPGN--ETICPPNIYIECADHT-----------LDSLGGG------PEGPCFCPTPCNLTR 506

  Fly   470 YNTEISQANFDLEEMLVAEGDTEFL-------KEYPGSQMSRLSIYFKQSQFITSKRSE---LYG 524
            |..|||...      :...|...:|       :.|.......|.::|   :.:||:..|   .||
Human   507 YGKEISMVR------IPNRGSARYLARKYNRNETYIRENFLVLDVFF---EALTSEAMEQRAAYG 562

  Fly   525 MTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRLFTNLKRL 565
            ::..|.:.||..|||:|.|||:|:|::.:.....:..|||:
Human   563 LSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRV 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:459966	113/546 (21%)
ASIC4	XP_054198812.1	ENaC	167..615	CDD:273304	116/561 (21%)