Protein Alignment rpk and ASIC5

DIOPT Version :9

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 124/574 - (21%)
• Similarity: 203/574 - (35%)
• Gaps: 191/574 - (33%)

  Fly    37 HEYCRNTSIHGVQYLGEQERPFRERIFWLFVFL--ISIYGCSTLIQSA-YTKW-TETPVIVSFAE 97
            |::..:||.||:..:.:.....| |:.||.|.|  :|:......|:.. |..| |.|.:.|.:.|
Human    39 HDFAISTSFHGIHNIVQNRSKIR-RVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVE 102

  Fly    98 KSTPVWNIPFPAVTVCS----ETKRVLK--------------QKGKETTYADLYSQFSEDMRASR 144
            |      :.|||||.|:    :|..|.|              ...:|.|.....|:.:.|..||.
Human   103 K------MEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASH 161

  Fly   145 VFRPENVSALEMEEFRTLLHVCNTQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRYFFYCRWLSRF 209
                :|.|.:|....:. .::.|:.::
Human   162 ----QNFSIVEFIRNKG-FYLNNSTLL-------------------------------------- 183

  Fly   210 GECETF--------FRKTLTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTL 266
             :||.|        |....||.|.|:|||                 .||.|:.:
Human   184 -DCEFFGKPCSPKDFAHVFTEYGNCFTFN-----------------HGETLQAK----------- 219

  Fly   267 ETGYALDSDVETFPARVLSAGARSGIFLALQSFKQEVDYACRGPVQGFKVGKFENVLLHAPDDVP 331
                           |.:|...| |:.| |.:..||.  ....|..|| |......::|:|..||
Human   220 ---------------RKVSVSGR-GLSL-LFNVNQEA--FTDNPALGF-VDAGIIFVIHSPKKVP 264

  Fly   332 QVSKQFVRIPMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFLSHER----------SLRFFKVYT 386
            |.....:..|:|....:.:                  ||....|:.          .|:.|..|:
Human   265 QFDGLGLLSPVGMHARVTI------------------RQVKTVHQEYPWGECNPNIKLQNFSSYS 311

  Fly   387 ESNCQLECLANFTLTKCGCVKFSMP-RNVDMPVCGEDK-IHCYDRAERELLVREFKRVKALNAGR 449
            .|.|..||.|.....:||||.|.:| ..::   |...| ..|.......:   |||.:  ...|.
Human   312 TSGCLKECKAQHIKKQCGCVPFLLPGYGIE---CDLQKYFSCVSPVLDHI---EFKDL--CTVGT 368

  Fly   450 ENSRSVESACNCMPACTSLVYNTEISQANFDLEEMLVAEGDTEFL-------KEYPGSQMSRLSI 507
            .||       :|..:|..:.|...||.::|..::.|      ::|       ::|....:.::.|
Human   369 HNS-------SCPVSCEEIEYPATISYSSFPSQKAL------KYLSKKLNQSRKYIRENLVKIEI 420

  Fly   508 YFKQSQFITSKRSELYGMTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRLFTN 561
            .:....:..:::.:...::|.||:.||..|||.|.|:::::|:|.:    ||||
Human   421 NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEY----LFTN 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:279230	118/561 (21%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	119/562 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147817
Domainoid	1	1.000	99	1.000	Domainoid score	I7068
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.700