DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rpk and ppk19

DIOPT Version :9

Sequence 1:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	128/577 - (22%)
Similarity:	224/577 - (38%)	Gaps:	145/577 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LTFR---RRRKAGSVACEGFITTYHEYCRNTSIHGVQYL-GEQERPFRERIFWLFVFL---ISIY 73
            |.||   |..|.....|..|        .:::|||:|:: |||.  ..:|..||.:.|   |:.:
  Fly    18 LRFRNNPRGIKFREKLCNSF--------AHSNIHGMQHVFGEQH--LWQRCLWLAIVLGAVITGF 72

  Fly    74 GCSTLIQSAYTKWTETPVIVSFAEKS-TPVWNIPFPAVTVCSETKRVLKQKGKETTYADLYSQFS 137
            ...|::...:::    .::||..|.: .||::|.||||.||.                  ::.|:
  Fly    73 SLYTVLMHRHSE----QLLVSLIETTQLPVYHIDFPAVAVCP------------------WNHFN 115

  Fly   138 EDMRASRVFR--PENVSALEMEEFRTLLHVCNTQIIE----EDIPLIAGDDL---DYF---DVLQ 190
            .....|...|  |.:.:|...|.||.||  .:..|:.    ..|.::...:|   .|.   |::.
  Fly   116 WQRAPSAFIRFLPRHPNAELRETFRQLL--ASMDIMNFSNFNRIRILTKRNLTGISYLKMTDLMN 178

  Fly   191 RMLPQFDRYFF--YCRWLSRFGECETFFRKTLTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLE 253
            .|..:.|..|.  .|.:.....:|...|.:..|.:|.|..||.:.:
  Fly   179 FMTYRCDELFVADSCVFDETPYDCCKLFVREQTVKGQCLVFNSMIS------------------- 224

  Fly   254 MENISSQHTAWTLETGYALDSDVETFPARVLSAGARSGIFLALQ---SFKQEVDYACRGPVQGFK 315
             ||...:|..            .:.:|.::.:||..||:...:.   ||...:|     .:..|.
  Fly   225 -ENSRKKHLI------------NQFYPHKLSTAGEDSGLKFTINASYSFMNNID-----ALTPFG 271

  Fly   316 VGKFENVLLHAPDDVPQVSKQFV-RIPMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFLSHERSL 379
            :    |:::..|   .|.|.:.: .:....|..:||.|.:...|....|..|.:|:|:...|::.
  Fly   272 M----NLMIKEP---RQWSNEMMYHLYPDTENFVAVHPLVTETSPNTYEMSPKKRRCYFDDEKNP 329

  Fly   380 RFFK---VYTESNCQLECLANFTLTKCGCVKFSMPR---NVD-MPVCGEDKIHCY-DRAERELLV 436
            .|..   .|...||.:.||.......|.|   |:|.   .:| :|.||.:...|. :.::....|
  Fly   330 TFQNTSLTYNRENCLVVCLHLVVWKTCQC---SLPAFLPPIDGVPECGINDAQCLGNNSDIFTYV 391

  Fly   437 REFKRVKALNAGRENSRSVESACNCMPACTSLVYNTEISQANFDLEEMLVAEGDTEFLKEYPGS- 500
            :...:.|.:|..|:.     ..|:|...|.|.:|...::....|                ||.:
  Fly   392 KMGDQEKYINDSRQG-----HFCDCPDNCNSRLYEMSLNVRKLD----------------YPKNS 435

  Fly   501 --QMSRLSIYFKQ---SQFITSKRSELYGMTEFLANCGGIFGLFMGFSILSLVEMIY 552
              |:.:..:|:.|   ::.||..:   |...:.|||.|||..|::|.|::|.:|:::
  Fly   436 TDQLIKAQVYYGQRVMTKIITKLK---YTNIDLLANFGGIISLYIGASVMSFIELLF 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:279230	121/549 (22%)
ppk19	NP_651708.2	ASC	39..489	CDD:279230	121/546 (22%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920