Protein Alignment rpk and ASIC1

DIOPT Version :10

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 116/619 - (18%)
• Similarity: 194/619 - (31%)
• Gaps: 247/619 - (39%)

  Fly    39 YCRNTSIHGVQYLGEQERPFRERIFWLFVFL----ISIYGCSTLIQSAY-----TKWTETPVIVS 94
            :..::::||:.::...||...:|..|...||    :.:..|:..:|..:     ||..|  |..|
Human    21 FASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDE--VAAS 83

  Fly    95 FAEKSTPVWNIPFPAVTVCSETKRVLKQKGKETTYADLYS------------------------- 134
                     .:.|||||:|:..:....|..|.    |||.
Human    84 ---------QLTFPAVTLCNLNEFRFSQVSKN----DLYHAGELLALLNNRYEIPDTQMADEKQL 135

  Fly   135 QFSEDMRASRVFRPENVSALEMEEFRTLLHVCNTQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRY 199
            :..:|....|.|:|:   ...|.||...                ||.|:.  |:|
Human   136 EILQDKANFRSFKPK---PFNMREFYDR----------------AGHDIR--DML---------- 169

  Fly   200 FFYCRWLSRFGECETFFRKTLTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAW 264
             ..|.:.......|. |:...|..|.|||||..|              .|.|
Human   170 -LSCHFRGEVCSAED-FKVVFTRYGKCYTFNSGR--------------DGRP------------- 205

  Fly   265 TLETGYALDSDVETFPARVLSAGARSGIFLALQSFKQEVDYACRGPVQG------FKVGKFENVL 323
            .|:|               :..|..:|:.:.|..  |:.:|.   ||.|      |:.|  ..|.
Human   206 RLKT---------------MKGGTGNGLEIMLDI--QQDEYL---PVWGETDETSFEAG--IKVQ 248

  Fly   324 LHAPDDVPQVSKQFVRIPMGKEVLIAVKP-------------NMITMSSGIAEYHPVRRQCFLSH 375
            :|:.|:.|.:.:....:..|.:..:|.:.             ..:||.|
Human   249 IHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDS---------------- 297

  Fly   376 ERSLRFFKVYTESNCQLECLANFTLTKCGCVKFSMPRNVDMPVCGEDKI-HCYDRAERELLVREF 439
              .|.||..|:.:.|:::|...:.:..|.|....||.  |.|.|..::. .|.|.|...|:.::
Human   298 --DLDFFDSYSITACRIDCETRYLVENCNCRMVHMPG--DAPYCTPEQYKECADPALDFLVEKD- 357

  Fly   440 KRVKALNAGRENSRSVESACNCMPACTSLVYNTEISQANFDLEEMLVAEGDTEFL-------KEY 497
                            :..|.|...|....|..|:|...      :.::...::|       ::|
Human   358 ----------------QEYCVCEMPCNLTRYGKELSMVK------IPSKASAKYLAKKFNKSEQY 400

  Fly   498 PGSQMSRLSIYFKQSQFITSKRSELYGMTEFL-----------------------ANC------- 532
            .|..:..|.|:|:...:.|.::.:.|.:...|                       |.|
Human   401 IGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEG 465

  Fly   533 ----------------GGIFGLFMGFSILSLVEM 550
                            ||..|||:|.|||:::|:
Human   466 PPPQRPFPKPCCLGDIGGQMGLFIGASILTVLEL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:459966	116/619 (19%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	116/619 (19%)