DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rpk and asic1b

DIOPT Version :9

Sequence 1:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	576	Identity:	111/576 - (19%)
Similarity:	191/576 - (33%)	Gaps:	187/576 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ITTYHEYCRNTSIHGVQYLGEQERPFRERI-FWLFVFLISI----------------YGCSTLIQ 80
            :.|:...|   |:||..::..:::.|..|. .|..|||::|                |...||:.
Zfish    66 LATFFGGC---SLHGANHVFVEDKKFSIRQGLWALVFLLAISMFLLQVVDRVIYYLQYDYVTLLD 127

  Fly    81 SAYTKWTETPVIVSFAEKSTPVWNIPFPAVTVCS-ETKRVLKQKGKETTYADLYSQ-----FSED 139
            ....|                  |:.|||:|:|: .|.|     ..:.:|:||...     :.::
Zfish   128 ERNAK------------------NMTFPAITLCNYNTFR-----RSQLSYSDLLFMGPLLGYEDN 169

  Fly   140 MRASRVFRPENVSALEMEEFRTLLHVCNTQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRYFFYCR 204
            |.......||                          |...|......:...|...:.|.....|.
Zfish   170 MAPGIPLAPE--------------------------PDRQGSRFSLAEFFNRTRHRMDDMLLECN 208

  Fly   205 WLSRFGEC-ETFFRKTLTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLET 268
            :..:  || ...:|:..|..|.|||||.              ...|.||.:
Zfish   209 FAGK--ECGAEHWREIFTRYGKCYTFNS--------------GQDGRPLLI-------------- 243

  Fly   269 GYALDSDVETFPARVLSAGARSGIFLALQSFKQEVDYACRGPVQG------FKVGKFENVLLHAP 327
                          ....|..:|:.:.|..  |:.:|.   ||.|      |:.|  ..|.:|..
Zfish   244 --------------TTKGGMGNGLEIMLDI--QQDEYL---PVWGETDETTFEAG--IKVQIHTQ 287

  Fly   328 DDVPQVSKQFVRIPMGKEVLIAVKPNMITMSS---GIAEYHPVRRQCFLSHERSLRFFKVYTESN 389
            |:.|.:.:....:..|.:..::.:...:|...   |..:..|:...          ||..|:.:.
Zfish   288 DEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKATPIDSD----------FFNTYSITA 342

  Fly   390 CQLECLANFTLTKCGCVKFSMPRNVDMPVCGEDKI-HCYDRAERELLVREFKRVKALNAGRENSR 453
            |:::|...:.:..|.|....||.  |.|.|..::. .|.|.|...|:.|:
Zfish   343 CRIDCETRYLVENCNCRMVHMPG--DAPYCTPEQYKECADPALDFLVERD--------------- 390

  Fly   454 SVESACNCMPACTSLVYNTEISQANFDLEEMLVAEGDTEFL-------KEYPGSQMSRLSIYFKQ 511
              ...|.|...|....|..|:|...      :.::...::|       ::|....:..|.|:|:.
Zfish   391 --NDYCVCETPCNMTRYGKELSFVR------IPSKASAKYLAKKYNKTEQYISDNIMVLDIFFEA 447

  Fly   512 SQFITSKRSELYGMTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRLFTNLKRLVK 567
            ..:.|.::.:.|.:...|.:.||..|||:|.|||:::|        ||..|..::|
Zfish   448 LNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILE--------LFDYLYEVIK 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:279230	106/553 (19%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57
		ASC	66..548	CDD:295594	111/576 (19%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.970