Protein Alignment rpk and asic2

DIOPT Version :10

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_005164179.1
• Gene: asic2 / 407669
• ZFINID: ZDB-GENE-040513-4
• Length: 564
• Species: Danio rerio
• Alignment Length: 561
• Identity: 126/561 - (22%)
• Similarity: 208/561 - (37%)
• Gaps: 150/561 - (26%)

  Fly    43 TSIHGVQYLGEQERPFRERIFWLFVF-----LISIYGCSTLIQSAYTKW----TETPVIVSFAEK 98
            |.:||::::.........|.||:..|     |:..:..:.|:.     |    |.|.|...:|::
Zfish    71 TRLHGLRHICSPSNSLSRRAFWMIAFCTCLGLLLSWSSNRLLH-----WLAFPTHTRVHTEWAKE 130

  Fly    99 STPVWNIPFPAVTVCSETKRVLKQKGKETTYADLY--SQFSEDMRASRVFRPENVSALE------ 155
                  :.||.||:|:.....|    ...|.:|||  ..:...:.|:|..||..:..|:
Zfish   131 ------LAFPTVTICNNNPVRL----YHLTKSDLYFAGHWLGLLLANRTARPLVLDLLQDDRRGW 185

  Fly   156 ---MEEFRTLLHVCNTQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRYFFYCRWLSRFGECETF-F 216
               :.:||..|.....:          |..|::.|   |:..|.:.....|::  |...|... |
Zfish   186 FSKLSDFRLFLPPRRFE----------GTSLEFMD---RLGHQLEDMLLACKY--RGEPCGAHNF 235

  Fly   217 RKTLTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLETGYALDSDVETFPA 281
            ....|..|.||.||   |.|           .|:              ||.|
Zfish   236 STVFTRYGKCYMFN---AAE-----------EGK--------------TLRT------------- 259

  Fly   282 RVLSAGARSGIFLALQSFKQEVDYACRGPVQG------FKVGKFENVLLHAPDDVPQVSKQFVRI 340
             .:..|..:|:.:.|..  |:.:|.   ||.|      |:.|  ..|.:|:..:.|.|.:....:
Zfish   260 -TMKGGTGNGLEIMLDI--QQDEYL---PVWGETEETAFEAG--VRVQIHSQAEPPFVHELGFGV 316

  Fly   341 PMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFLSHERSLRFFKVYTESNCQLECLANFTLTKCGC 405
            ..|.:..:|.:...:|.      ..|...:| :|.......|:||:.|.|::||...:.:..|.|
Zfish   317 APGFQTFVATQEQRLTY------LPPPWGEC-VSRALDSGLFQVYSVSACRIECETRYIVENCNC 374

  Fly   406 VKFSMPRNVDMPVCGEDKIHCYDRAERELLVREFKRVKALNAGRENSRSVESA-CNCMPACTSLV 469
            ....||.  |.|.|..::..  |.||..|        .||:|       ||.. |.|...|....
Zfish   375 RMVYMPG--DSPYCTPEQYK--DCAEPAL--------AALSA-------VEGTNCICRSPCNMTR 420

  Fly   470 YNTEISQANFDLEEMLVAEGDTEFL-------KEYPGSQMSRLSIYFKQSQFITSKRSELYGMTE 527
            ||.|:|...      :.::....:|       ::|....:..|.::|:...:.|.::.:.|.:..
Zfish   421 YNKELSMVK------IPSKTSARYLEKKFNRSEKYITDNILVLDVFFEALNYETIEQKKAYEVAG 479

  Fly   528 FLANCGGIFGLFMGFSILSLVEMI-YHFTL---RLFTNLKR 564
            .|.:.||..|||:|.|||:|:|:. |.:.:   ||...|.|
Zfish   480 LLGDIGGQMGLFIGASILTLLELFDYAYEVVKERLLDLLNR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:459966	121/544 (22%)
asic2	XP_005164179.1	ENaC	71..538	CDD:273304	126/561 (22%)