Protein Alignment rpk and ASIC2

DIOPT Version :10

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 125/567 - (22%)
• Similarity: 208/567 - (36%)
• Gaps: 166/567 - (29%)

  Fly    45 IHGVQYL--GEQER--PFRERIFWLFVFLISIYGCSTLIQSAYTKWTETPVI--VSFAEKSTPV- 102
            :||::::  |....  .|:.|..|:..|..| :|   |:.|    |:...::  :|| ...|.|
Human    66 LHGLRHMCAGRTAAGGSFQRRALWVLAFCTS-FG---LLLS----WSSNRLLYWLSF-PSHTRVH 121

  Fly   103 --WN--IPFPAVTVCSETKRVLKQKGKETTYADLY--SQFSEDMRASRVFRPENVSAL------- 154
              |:  :||||||||:.......:..|    .|||  ..:...:..:|..|| .||.|
Human   122 REWSRQLPFPAVTVCNNNPLRFPRLSK----GDLYYAGHWLGLLLPNRTARP-LVSELLRGDEPR 181

  Fly   155 -----EMEEFRTLL---HVCNTQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRYFFYCRWLSRFGE 211
                 ::.:||..|   |             ..|....:.|   |:..|.:.....|::.   ||
Human   182 RQWFRKLADFRLFLPPRH-------------FEGISAAFMD---RLGHQLEDMLLSCKYR---GE 227

  Fly   212 -CETF-FRKTLTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLETGYALDS 274
             |... |....|:.|.||.||.              ...|:||             |.|
Human   228 LCGPHNFSSVFTKYGKCYMFNS--------------GEDGKPL-------------LTT------ 259

  Fly   275 DVETFPARVLSAGARSGIFLALQSFKQEVDYACRGPVQG------FKVGKFENVLLHAPDDVPQV 333
                     :..|..:|:.:.|..  |:.:|.   |:.|      |:.|  ..|.:|:..:.|.:
Human   260 ---------VKGGTGNGLEIMLDI--QQDEYL---PIWGETEETTFEAG--VKVQIHSQSEPPFI 308

  Fly   334 SKQFVRIPMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFLSHERSLRFFKVYTESNCQLECLANF 398
            .:....:..|.:..:|.:...:|.      ..|...:| .|.|..|.||.||:.:.|:::|...:
Human   309 QELGFGVAPGFQTFVATQEQRLTY------LPPPWGEC-RSSEMGLDFFPVYSITACRIDCETRY 366

  Fly   399 TLTKCGCVKFSMPRNVDMPVC-GEDKIHCYDRAERELLVREFKRVKALNAGRENSRSVESACNCM 462
            .:..|.|....||.  |.|.| .|....|.:.|...|..::                 .:.|.|.
Human   367 IVENCNCRMVHMPG--DAPFCTPEQHKECAEPALGLLAEKD-----------------SNYCLCR 412

  Fly   463 PACTSLVYNTEISQANFDLEEMLVAEGDTEFL-------KEYPGSQMSRLSIYFKQSQFITSKRS 520
            ..|....||.|:|...      :.::...::|       ::|....:..|.|:|:...:.|.::.
Human   413 TPCNLTRYNKELSMVK------IPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQK 471

  Fly   521 ELYGMTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRLFTNLKRLVK 567
            :.|.:...|.:.||..|||:|.|||:::|        ||..:..|:|
Human   472 KAYEVAALLGDIGGQMGLFIGASILTILE--------LFDYIYELIK 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:459966	121/550 (22%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	125/567 (22%)