DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rpk and ppk12

DIOPT Version :9

Sequence 1:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	147/558 - (26%)
Similarity:	245/558 - (43%)	Gaps:	94/558 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EGFITTYHEYCRNTSIHGVQYLGEQERPFRERIFWLFVFLISIYGCSTLIQSAYTKWTETPVIVS 94
            :.|:.:..::...||:||::::|:......||.|:|..|:.::.....||.:.|.||..||||:.
  Fly    20 KSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIG 84

  Fly    95 FAEKSTPVWNIPFPAVTVC--SETKRVL----KQKGKETTYADLYSQFSEDMRASRVFRPENVSA 153
            .:.::|.:..:||||:|:|  ::.:|.|    ::...|:....|..: |:...:|..
  Fly    85 ISPQATSILKVPFPAITICNMNQVQRSLVANYREGSNESALLKLLCE-SDSWESSEA-------- 140

  Fly   154 LEMEEFRTLLHVCNTQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRYFFYCRWLSRFGECETFFRK 218
              .|||.....|.|...|.|.:.       ::....:|||       .:||:.:....|...|::
  Fly   141 --DEEFSASNFVTNNLKISEFVS-------NHSQSCERML-------LFCRFSAVERNCSQLFQQ 189

  Fly   219 TLTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENIS------SQHTAWTLETGYALDSDVE 277
            .||:||:|..||       ::...|.|    :|....|.:      .:...|..|:||......:
  Fly   190 ILTDEGLCCVFN-------FQPPEYLY----KPFANNNRNLTNSDGFESVMWDPESGYPEQLPPK 243

  Fly   278 TFPARVLSAGARSGIFLALQSFKQEVDYAC---RGPVQGFKVGKFENVLLHAPDDVPQVSKQFVR 339
            .:||.....|...|....|.:  :..:|.|   .||  |||      |..|.|.:||:|.:..:.
  Fly   244 FYPATASGTGITLGFTAVLDA--EMGEYYCSSTNGP--GFK------VYFHNPIEVPKVKEAGLI 298

  Fly   340 IPMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFLSHERSLRFFKVYTESNCQLECLANFTLTKCG 404
            ..:|.|....::.........|.......|||...:|:.|.|:::||..||:.||||.|....|.
  Fly   299 SAIGYETNYRIEMVRAEAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCS 363

  Fly   405 CVKFSMP---RNVDMPVCGEDKIHCYDRAERELLVREFKRVKALNAGRENSRSVESAC--NCMPA 464
            |:.|..|   .|..  :|......|..||:                 |.::|...:.|  .|:|:
  Fly   364 CIPFDHPLIYSNAS--ICSMGDTSCVRRAQ-----------------RASNRPGWAKCRQQCLPS 409

  Fly   465 CTSLVY-----NTEISQANFDLEEMLVAEGDTEFLKEYPGSQMSRLSIYFKQSQFITSKRSELYG 524
            |..|.|     :..::..||.|...||    ..|.|.|....::.:::||::|.:..:.::...|
  Fly   410 CFDLNYLASGFSFPLASNNFQLANALV----ESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVG 470

  Fly   525 MTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRLFTNL 562
            :||||:|.||:.|||||||::||.|::|...|:....|
  Fly   471 LTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPLAEL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:279230	143/537 (27%)
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	143/539 (27%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	143/538 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456757
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	1	0.950	-	0	Normalized mean entropy	S7217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	12	11.750