DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rpk and Asic2

DIOPT Version :9

Sequence 1:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_037024.2	Gene:	Asic2 / 25364	RGDID:	2017	Length:	563	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	123/569 - (21%)
Similarity:	207/569 - (36%)	Gaps:	166/569 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 TSIHGVQYL--GEQER--PFRERIFWLFVFLISIYGCSTLIQSAYTKWTETPVI--VSFAEKSTP 101
            |.:||::::  |....  .|:.|..|:..|      |::|  .....|:...::  :|| ...|.
  Rat    64 TKLHGLRHMCAGRTAAGGSFQRRALWVLAF------CTSL--GLLLSWSSNRLLYWLSF-PSHTR 119

  Fly   102 V---WN--IPFPAVTVCSETKRVLKQKGKETTYADLY--SQFSEDMRASRVFRPENVSAL----- 154
            |   |:  :||||||||:.......:..|    .|||  ..:...:..:|..|| .||.|
  Rat   120 VHREWSRQLPFPAVTVCNNNPLRFPRLSK----GDLYYAGHWLGLLLPNRTARP-LVSELLRGDE 179

  Fly   155 -------EMEEFRTLL---HVCNTQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRYFFYCRWLSRF 209
                   ::.:||..|   |             ..|....:.|   |:..|.:.....|::.
  Rat   180 PRRQWFRKLADFRLFLPPRH-------------FEGISAAFMD---RLGHQLEDMLLSCKYR--- 225

  Fly   210 GE-CETF-FRKTLTEEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLETGYAL 272
            || |... |....|:.|.||.||.              ...|:||             |.|
  Rat   226 GELCGPHNFSSVFTKYGKCYMFNS--------------GEDGKPL-------------LTT---- 259

  Fly   273 DSDVETFPARVLSAGARSGIFLALQSFKQEVDYACRGPVQG------FKVGKFENVLLHAPDDVP 331
                       :..|..:|:.:.|..  |:.:|.   |:.|      |:.|  ..|.:|:..:.|
  Rat   260 -----------VKGGTGNGLEIMLDI--QQDEYL---PIWGETEETTFEAG--VKVQIHSQSEPP 306

  Fly   332 QVSKQFVRIPMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFLSHERSLRFFKVYTESNCQLECLA 396
            .:.:....:..|.:..:|.:...:|.      ..|...:| .|.|..|.||.||:.:.|:::|..
  Rat   307 FIQELGFGVAPGFQTFVATQEQRLTY------LPPPWGEC-RSSEMGLDFFPVYSITACRIDCET 364

  Fly   397 NFTLTKCGCVKFSMPRNVDMPVC-GEDKIHCYDRAERELLVREFKRVKALNAGRENSRSVESACN 460
            .:.:..|.|....||.  |.|.| .|....|.:.|...|..::                 .:.|.
  Rat   365 RYIVENCNCRMVHMPG--DAPFCTPEQHKECAEPALGLLAEKD-----------------SNYCL 410

  Fly   461 CMPACTSLVYNTEISQANFDLEEMLVAEGDTEFL-------KEYPGSQMSRLSIYFKQSQFITSK 518
            |...|....||.|:|...      :.::...::|       ::|....:..|.|:|:...:.|.:
  Rat   411 CRTPCNLTRYNKELSMVK------IPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIE 469

  Fly   519 RSELYGMTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRLFTNLKRLVK 567
            :.:.|.:...|.:.||..|||:|.|:|:::|        ||..:..|:|
  Rat   470 QKKAYEVAALLGDIGGQMGLFIGASLLTILE--------LFDYIYELIK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:279230	119/552 (22%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	123/569 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I5010
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970