Protein Alignment rpk and Asic4

DIOPT Version :10

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: XP_036020902.1
• Gene: Asic4 / 241118
• MGIID: 2652846
• Length: 586
• Species: Mus musculus
• Alignment Length: 586
• Identity: 118/586 - (20%)
• Similarity: 199/586 - (33%)
• Gaps: 166/586 - (28%)

  Fly    39 YCRNTSIHGV-QYLGEQERPFRERIFWLFVFLIS----IYGCSTLIQSAYTKWTETPVIVSFAEK 98
            :...:::||: :..|......| |..|....|.|    :|..::|.:...|:    |.:|:. :.
Mouse    45 FASTSTLHGLGRACGPGPHGLR-RTLWALALLTSLAAFLYQAASLARGYLTR----PHLVAM-DP 103

  Fly    99 STPVWNIPFPAVTVCSETKRVLKQKGKETTYADLYSQFSEDMRASRVFRPENVSALEMEEFRTLL 163
            :.|.....|||||:|:    :.:.:....:.||             :|...|::.|..:
Mouse   104 AAPAPVAGFPAVTLCN----INRFRHSALSDAD-------------IFHLANLTGLPPK------ 145

  Fly   164 HVCNTQIIEEDIPLIAG---DDLDYFDVLQRMLPQFDRYFFYCRWLSRFGECE-TFFRKTLTEEG 224
                    :.|....||   .:.|..|:|.|...|.......|.:...  .|. :.|....|..|
Mouse   146 --------DRDGHRAAGLRYPEPDMVDILNRTGHQLADMLKSCNFSGH--HCSASNFSVVYTRYG 200

  Fly   225 ICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLETGYALDSDVETFPARVLSAGAR 289
            .|||||                  .:|                        ..:.|:|  :.|..
Mouse   201 KCYTFN------------------ADP------------------------QSSLPSR--AGGMG 221

  Fly   290 SGIFLALQSFKQEVDYACRGPV------QGFKVGKFENVLLHAPDDVPQVSKQFVRIPMGKEVLI 348
            ||:.:.|..  |:.:|.   |:      ..|:.|  ..|.:|:.::.|.:.:....:..|.:..:
Mouse   222 SGLEIMLDI--QQEEYL---PIWRETNETSFEAG--IRVQIHSQEEPPYIHQLGFGVSPGFQTFV 279

  Fly   349 AVKPNMITMSSGIAEYHP-----VRRQCFLSHERSLRFFKVYTESNCQLECLANFTLTKCGCVKF 408
            :.:...:|       |.|     .|.:..| .|..|:.:..|:.|.|:|.|.....|.:|.|...
Mouse   280 SCQEQRLT-------YLPQPWGNCRAESEL-REPELQGYSAYSVSACRLRCEKEAVLQRCHCRMV 336

  Fly   409 SMPRNVDMPVCG----EDKIHCYDRAERELLVREFKRVKA-------LNAGREN----------- 451
            .||.....||.|    ..:.....|..|....|.:...:.       |:.|.|.
Mouse   337 HMPGGHLQPVFGATLLSSRTSRRQRCMRTTCTRIYTHERVLMCMSGYLHMGNETICPPNIYIECA 401

  Fly   452 -------SRSVESACNCMPACTSLVYNTEISQANFDLEEMLVAEGDTEFL-------KEYPGSQM 502
                   ....|..|.|...|....|..|||...      :...|...:|       :.|.....
Mouse   402 DHTLDSLGGGSEGPCFCPTPCNLTRYGKEISMVK------IPNRGSARYLARKYNRNETYIRENF 460

  Fly   503 SRLSIYFKQSQFITSKRSE---LYGMTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRLFTNLKR 564
            ..|.::|   :.:||:..|   .||::..|.:.||..|||:|.|||:|:|::.:.....:..|||
Mouse   461 LVLDVFF---EALTSEAMEQQAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKR 522

  Fly   565 L 565
            :
Mouse   523 V 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:459966	115/571 (20%)
Asic4	XP_036020902.1	ENaC	40..535	CDD:273304	118/586 (20%)