Protein Alignment rpk and Scnn1b

DIOPT Version :10

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_035455.1
• Gene: Scnn1b / 20277
• MGIID: 104696
• Length: 638
• Species: Mus musculus
• Alignment Length: 645
• Identity: 137/645 - (21%)
• Similarity: 208/645 - (32%)
• Gaps: 219/645 - (33%)

  Fly    35 TYHE----YCRNTSIHGVQYLGEQERPFRERIFWLFVFLISIYGC---STLIQSAYTKWTETPVI 92
            ||.|    ||.||:.||.:.: ..|.|.::.:::|...|.:...|   ...||: |..| |..|.
Mouse    21 TYKELLVWYCNNTNTHGPKRI-ICEGPKKKAMWFLLTLLFACLVCWQWGVFIQT-YLSW-EVSVS 82

  Fly    93 VSFAEKSTPVWNIPFPAVTVC-------SETKRVLKQKGKETTYADLYSQFSEDMRA--SRVFRP 148
            :|...|:     :.|||||||       |:.|.:||         ||    .|.|.|  .::..|
Mouse    83 LSMGFKT-----MNFPAVTVCNSSPFQYSKVKHLLK---------DL----DELMEAVLEKILAP 129

  Fly   149 E---------------NVSALEMEEFRTLLH--------------------VCNTQIIEEDIPLI 178
            |               |.:.|.:.:.|...|                    .||.|..:..:.|.
Mouse   130 EASHSNTTRTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLC 194

  Fly   179 AGDD--------------------LDYFDVLQRMLPQF--------DRYFFYCRWLSRFGECETF 215
            :.:.                    |...::..::|||.        ||....|    .|| .|..
Mouse   195 SANGTVCTLRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILAC----LFG-TEPC 254

  Fly   216 FRKTLT-----EEGICYTFNGLRATEIYRDDTYQYQHSGEPLEMENISSQHTAWTLETGYALDSD 275
            ..:..|     :.|.||.||                                 |.:..
Mouse   255 SHRNFTPIFYPDYGNCYIFN---------------------------------WGMTE------- 279

  Fly   276 VETFPARVLSAGARSGIFLALQSFKQEVDYACRGPVQGFKVGKFENVLLHAPDDVPQVSKQFVRI 340
             ||.|:  .:.|...|:.|.| ...|| ||.   |......|  ..::||.....|.:.::.:..
Mouse   280 -ETLPS--ANPGTEFGLKLIL-DIGQE-DYV---PFLASTAG--ARLMLHEQRTYPFIREEGIYA 334

  Fly   341 PMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFL--SHERSLRFFKVYTES----NCQLECLANFT 399
            ..|.|..|.|..:.:....  ..|.|    |.:  |.......:.||..:    .|...|..:..
Mouse   335 MAGTETSIGVLVDKLQRKG--EPYSP----CTMNGSDVAIKNLYSVYNTTYSIQACLHSCFQDHM 393

  Fly   400 LTKCGCVKFSMP--------RNVDMPVCGEDKIHCYDRAERELLVREFKRVKALNAGRENSRSVE 456
            :..|.|..:..|        .|.|.|    |..:||...:..:..||
Mouse   394 IRNCSCGHYLYPLPEGEKYCNNRDFP----DWAYCYLNLQMSVTQRE------------------ 436

  Fly   457 SAC--NCMPACTSLVYNTEISQANFDLE-------EMLVAEGDTEFLKEYPGSQMSRLSIYFKQS 512
             .|  .|..:|....|...||.|::..|       .:|..|.|...........:.:|:|||::.
Mouse   437 -TCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEF 500

  Fly   513 QFITSKRSELYGMTEFLANCGGIFGLFMGFSILSLVE-------MIYHFTLRLFTNLKRL 565
            .:.|.:.|....:...|:|.||.||.:||.|:|.|:|       .|:...::|..:.|.|
Mouse   501 NYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLVASCKGL 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:459966	130/622 (21%)
Scnn1b	NP_035455.1	ENaC	21..621	CDD:273304	137/645 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..620
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51168	614..618