Protein Alignment rpk and mec-4

DIOPT Version :10

• Sequence 1: NP_001246909.1
• Gene: rpk / 40580
• FlyBaseID: FBgn0022981
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_510712.2
• Gene: mec-4 / 181728
• WormBaseID: WBGene00003168
• Length: 768
• Species: Caenorhabditis elegans
• Alignment Length: 722
• Identity: 136/722 - (18%)
• Similarity: 217/722 - (30%)
• Gaps: 271/722 - (37%)

  Fly    36 YHEYCRNTSIHGVQYLGEQERPFRERIFWLFVFLISIYGCSTLI----QSAYTKWTETPVIVSFA 96
            :.|:|..||.||:..:||....: .|..|:.:||    ||..::    ||...|:.....||...
 Worm    84 FKEFCYKTSAHGIPMIGEAPNVY-YRAVWVVLFL----GCMIMLYLNAQSVLDKYNRNEKIVDIQ 143

  Fly    97 EKSTPVWNIPFPAVTVC------------------------------------------------ 113
            .|..   ..||||:|:|
 Worm   144 LKFD---TAPFPAITLCNLNPYKASLATSVDLVKRTLSAFDGAMGKAGGNKDHEEEREVVTEPPT 205

  Fly   114 --SETKRVLKQKGKETTYADLYSQFSE----------------------------DMRASRVFRP 148
              :.|.:..:::||.    ||...|.|                            :....:||
 Worm   206 TPAPTTKPARRRGKR----DLSGAFFEPGFARCLCGSQGSSEQEDKDEEKEEELLETTTKKVF-- 264

  Fly   149 ENVSALE-----MEEF---------------RTLLHVCNTQIIEEDIPLIAGDDLDYFDVLQRML 193
             |::..:     |||:               ..::..|.::..:.|.|  .|.|       .|.:
 Worm   265 -NINDADEEWDGMEEYDNEHYENYDVEATTGMNMMEECQSERTKFDEP--TGFD-------DRCI 319

  Fly   194 PQFDR-------YFFYCRWLSRFGECETFFRKTLTEEGIC----YTFNGLRATEIYRDDTYQYQH 247
            ..|||       .|....|.:.  ||:     |..|...|    .|..|.|:..|.....:...:
 Worm   320 CAFDRSTHDAWPCFLNGTWETT--ECD-----TCNEHAFCTKDNKTAKGHRSPCICAPSRFCVAY 377

  Fly   248 SGE--PLEMENISSQHTAWTLETGYALDSDVETFPAR---------VLSAGARSGIFLA------ 295
            :|:  |:|:         ||...|.....|.....|.         .:...|:..|..|
 Worm   378 NGKTPPIEI---------WTYLQGGTPTEDPNFLEAMGFQGMTDEVAIVTKAKENIMFAMATLSM 433

  Fly   296 -----LQSFKQEVDYAC---------------------------------------RGPVQGFKV 316
                 |.:.|:|:.:.|                                       .||:.|.::
 Worm   434 QDRERLSTTKRELVHKCSFNGKACDIEADFLTHIDPAFGSCFTFNHNRTVNLTSIRAGPMYGLRM 498

  Fly   317 GKFENVLLHAPDDVPQVSKQFVRI------------------PMGKEVLIAVKPNMITMSSGIAE 363
                .|.::|.|.:|......||:                  |.|......::  :..||...|.
 Worm   499 ----LVYVNASDYMPTTEATGVRLTIHDKEDFPFPDTFGYSAPTGYVSSFGLR--LRKMSRLPAP 557

  Fly   364 YHPVRRQCFLSHERSLRFFKVYTES--NCQLECLANFTLTKCGC--VKFSMPRNVDMPVCGEDKI 424
            |    ..|....:.|...:..|..|  .|...|.....|.:|.|  .:|.:|.|..
 Worm   558 Y----GDCVPDGKTSDYIYSNYEYSVEGCYRSCFQQLVLKECRCGDPRFPVPENAR--------- 609

  Fly   425 HCYDRAERELLVREFKRVKALNAGRENSRSVESA--CNCMPACTSLVYNTEISQANFDLEEMLVA 487
            || |.|:.  :.|     |.|:|...:...:..:  |.|...|...:|:...|.|.:....:.:.
 Worm   610 HC-DAADP--IAR-----KCLDARMNDLGGLHGSFRCRCQQPCRQSIYSVTYSPAKWPSLSLQIQ 666

  Fly   488 EGD-----TEFLKEYPGSQMSRLSIYFKQSQFITSKRSELYGMTEFLANCGGIFGLFMGFSILSL 547
            .|.     .|..|.|. ...:.:.::::|..|.....||.||....||:.||..||:.|.|.|:.
 Worm   667 LGSCNGTAVECNKHYK-ENGAMVEVFYEQLNFEMLTESEAYGFVNLLADFGGQLGLWCGISFLTC 730

  Fly   548 VEMIYHF 554
            .|.::.|
 Worm   731 CEFVFLF 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:459966	134/715 (19%)
mec-4	NP_510712.2	deg-1	86..736	CDD:273309	135/717 (19%)