DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rpk and Asic2

DIOPT Version :9

Sequence 1:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_006532059.1	Gene:	Asic2 / 11418	MGIID:	1100867	Length:	596	Species:	Mus musculus

Alignment Length:	596	Identity:	128/596 - (21%)
Similarity:	208/596 - (34%)	Gaps:	187/596 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 TSIHGVQYL--GEQER--PFRERIFWLFVFLISIYGCSTLIQSAYTKWTETPVI--VSFAEKSTP 101
            |.:||::::  |....  .|:.|..|:..|      |::|  .....|:...::  :|| ...|.
Mouse    64 TKLHGLRHMCAGRTAAGGSFQRRALWVLAF------CTSL--GLLLSWSSNRLLYWLSF-PSHTR 119

  Fly   102 V---WN--IPFPAVTVCSETKRVLKQKGKETTYADLY--SQFSEDMRASRVFRPENVSAL----- 154
            |   |:  :||||||||:.......:..|    .|||  ..:...:..:|..|| .||.|
Mouse   120 VHREWSRQLPFPAVTVCNNNPLRFPRLSK----GDLYYAGHWLGLLLPNRTARP-LVSELLRGDE 179

  Fly   155 -------EMEEFRTLL---HVCNTQIIEEDIPLIAGDDLDYFDVLQRML---------------- 193
                   ::.:||..|   |.       |.|.....|.|.:  .|:.||
Mouse   180 PRRQWFRKLADFRLFLPPRHF-------EGISAAFMDRLGH--QLEDMLLSCKYRGELCGPHNFS 235

  Fly   194 -------------PQFDRYFFYCRWLSRFGECETFFRKTLTEEGICYTFNGLRATEIYRDDTYQY 245
                         |...|.....||....|.....|    |:.|.||.||.
Mouse   236 SVSCPPREPALSDPALPRSPEALRWAPGTGHQAPVF----TKYGKCYMFNS-------------- 282

  Fly   246 QHSGEPLEMENISSQHTAWTLETGYALDSDVETFPARVLSAGARSGIFLALQSFKQEVDYACRGP 310
            ...|:||             |.|               :..|..:|:.:.|..  |:.:|.   |
Mouse   283 GEDGKPL-------------LTT---------------VKGGTGNGLEIMLDI--QQDEYL---P 314

  Fly   311 VQG------FKVGKFENVLLHAPDDVPQVSKQFVRIPMGKEVLIAVKPNMITMSSGIAEYHPVRR 369
            :.|      |:.|  ..|.:|:..:.|.:.:....:..|.:..:|.:...:|.      ..|...
Mouse   315 IWGETEETTFEAG--VKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTY------LPPPWG 371

  Fly   370 QCFLSHERSLRFFKVYTESNCQLECLANFTLTKCGCVKFSMPRNVDMPVC-GEDKIHCYDRAERE 433
            :| .|.|..|.||.||:.:.|:::|...:.:..|.|....||.  |.|.| .|....|.:.|...
Mouse   372 EC-RSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPG--DAPFCTPEQHKECAEPALGL 433

  Fly   434 LLVREFKRVKALNAGRENSRSVESACNCMPACTSLVYNTEISQANFDLEEMLVAEGDTEFL---- 494
            |..::                 .:.|.|...|....||.|:|...      :.::...::|
Mouse   434 LAEKD-----------------SNYCLCRTPCNLTRYNKELSMVK------IPSKTSAKYLEKKF 475

  Fly   495 ---KEYPGSQMSRLSIYFKQSQFITSKRSELYGMTEFLANCGGIFGLFMGFSILSLVEMIYHFTL 556
               ::|....:..|.|:|:...:.|.::.:.|.:...|.:.||..|||:|.|||:::|
Mouse   476 NKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILE------- 533

  Fly   557 RLFTNLKRLVK 567
             ||..:..|:|
Mouse   534 -LFDYIYELIK 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rpk	NP_001246909.1	ASC	39..552	CDD:279230	124/579 (21%)
Asic2	XP_006532059.1	ASC	64..590	CDD:383197	128/596 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I5086
Isobase	1	0.950	-	0	Normalized mean entropy	S7217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.820