DRSC/TRiP Functional Genomics Resources

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Protein Alignment cacna1sb and para

DIOPT Version :9

Sequence 1:NP_999891.1 Gene:cacna1sb / 405791 ZFINID:ZDB-GENE-051227-1 Length:1847 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2074 Identity:492/2074 - (23%)
Similarity:823/2074 - (39%) Gaps:640/2074 - (30%)


- Green bases have known domain annotations that are detailed below.


Zfish    61 NPFRKACTNIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTLESLEYIFLVIFTLECF 125
            ||.|:....|:....|.:.|:.||..||:.:.    ||      |..|:||.|.||..|:|.|..
  Fly   140 NPIRRVAIYILVHPLFSLFIITTILVNCILMI----MP------TTPTVESTEVIFTGIYTFESA 194

Zfish   126 LKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTIDTITGVQKEKGGGFDMKALRAFRVL 190
            :|::|.|.:.....|||:.||.||||::.:...|:.:|.              .::.|||.||||
  Fly   195 VKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDL--------------GNLAALRTFRVL 245

Zfish   191 RPLRLVSGVPSLQVVMSSVLKSMLPLFHILLLVFFMVTIYAIMGLELFKCKMHKTC--------- 246
            |.|:.|:.||.|:.::.:|::|:..|..:::|..|.::::|:|||:::...:.:.|         
  Fly   246 RALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGS 310

Zfish   247 ----------YYQGTNIIALRENEKPS-P-CAQAGNGRRCTINGTECRDGW-PGPNFGITHFDNF 298
                      |:...:.....|:|..| | |.......:|. :...|..|: |.||:|.|.||:|
  Fly   311 WGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCD-DDYVCLQGFGPNPNYGYTSFDSF 374

Zfish   299 GFAMLTVFQCITTESWTDVLYWINDAMGNDWPWIYFLSLIMLGSFFILNLVLGVLSGEFTKEREK 363
            |:|.|:.|:.:|.:.|.|:...:..|.| .|..::|:.:|.||||:::||:|.:::..:.:.::|
  Fly   375 GWAFLSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKK 438

Zfish   364 SRSR--GEWQVLRERQQ--------MDE----------DLKGYMEWITHAEVM------------ 396
            :...  .|.:.:||.::        ::|          |.....|...|.|:.            
  Fly   439 AEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYEL 503

Zfish   397 ---------DGDSDAMLLLRKDTGSETDSL----------YKMEGINKV---------------- 426
                     |.:.:.|.:...:..||:.|:          ::...:.||                
  Fly   504 FVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRR 568

Zfish   427 -------------------------------------------------------------VYFY 430
                                                                         ||:.
  Fly   569 GSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYG 633

Zfish   431 RLARR------------------------------------------------------------ 435
            .|..|                                                            
  Fly   634 NLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTN 698

Zfish   436 ---------------------------------------------WNIVIRRK------------ 443
                                                         .|.:|.:.            
  Fly   699 HKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGV 763

Zfish   444 -------------------------------------CHGWVKSKSFNWWVLIVV---------- 461
                                                 |..|:|   |..||.::|          
  Fly   764 SVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLK---FQEWVSLIVFDPFVELFIT 825

Zfish   462 ---LLNTLVIATEHHNQTEGLTNFQDTANVILLACFTIEMIMKMYAFGPRSYFMSIFNRFDCFVV 523
               ::||:.:|.:||:..:.:.....:.|....|.|.||..||:.|..|:.||...:|.||..:|
  Fly   826 LCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIV 890

Zfish   524 TIGILEIILVGSGIMTPLGISVMRCIRLLRLFKLTKYWTSLNNLVVSLLNSVKSIASLLLLLFLF 588
            .:.:||:     |:....|:||:|..||||:|||.|.|.:||.|:..:..::.::.:|..:|.:.
  Fly   891 ALSLLEL-----GLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCII 950

Zfish   589 IVIFALLGMQVFGGKFN-----FPDRPIQRSNFDNFPQALISVFQVLTGE----EWDTIMYNGIM 644
            |.|||::|||:||..::     |||..:.|.||.:|..:.:.||:||.||    .|| .||.|  
  Fly   951 IFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWD-CMYVG-- 1012

Zfish   645 AHGGPKSPGILVSIYFIILYVCGNFVLLNVFLAIAVDNLAEAESLAAAQKERAEER--------- 700
                    .:....:|:...|.||.|:||:|||:.:.|.. :.||:|...:....:         
  Fly  1013 --------DVSCIPFFLATVVIGNLVVLNLFLALLLSNFG-SSSLSAPTADNDTNKIAEAFNRIG 1068

Zfish   701 ----------------ARKKLMKPLPEKTEEEK-------------------------------- 717
                            .|.||...:.::...|:                                
  Fly  1069 RFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGHD 1133

Zfish   718 -----ALMAKRLMESRQKT----EGM------------PTTAK----------LKIDEFESNVNE 751
                 .|:.|.:.|..|..    :||            |..:|          ..|:.:.|:.|.
  Fly  1134 EILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNR 1198

Zfish   752 VKDPFPPADFPGDDEEEEPEIPISPRPRPMADLQLKETVVPMPEASSFFIFG------------- 803
               ||......|..|..|.|   ..|.....||.|.|.:....|.....:.|             
  Fly  1199 ---PFKDESHKGSAETMEGE---EKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILD 1257

Zfish   804 -------PQNKFRKL---------------------CHRIINHTTFTNIILLFILLSSISLAAED 840
                   |.:.::|.                     ..::|.:..|...::..||:||::||.||
  Fly  1258 EYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALED 1322

Zfish   841 ---PIDPHSFRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHPGSFCRNSFNILDLIVVAVSLLS 902
               |..|  ....:|.|.|.:||.:|.:|:::|....|..:    :..|::..||.::|.|||::
  Fly  1323 VHLPQRP--ILQDILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIVMVSLIN 1381

Zfish   903 MG---MESSTISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIVLVTMLLDFMFSC 964
            ..   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|::||.::...:|:.
  Fly  1382 FVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAI 1446

Zfish   965 IGVQLFKGTLFYCTDPLQKTAEQCQGTFLKH-VQNSLHDTEIHQRRWVNSDFNFDNVLNGMLALF 1028
            :|||||.|..|.|        |...||.|.| :..:.:..|.....||||..|||:|.|..|.||
  Fly  1447 MGVQLFAGKYFKC--------EDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLF 1503

Zfish  1029 TISTFEGWPEILYKAIDSYDVDTGPLYNNRVGISIFFIIYIIIIAFFMMNIFVGFVIVTFQRQGE 1093
            .::||:||.:|:..||||.:||..|:....:.:.::|:.:||..:||.:|:|:|.:|..|..|.:
  Fly  1504 QVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKK 1568

Zfish  1094 QEYKNCELDKNQRQCVQY-ALK----ARPLKCYIPE---NPHQYRVWYLVTSCYFEYLMFFLIML 1150
            :...:.|:...:.|...| |:|    .:|||. ||.   .| |..|:.:||...|:.::...|.|
  Fly  1569 KAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKA-IPRPRWRP-QAIVFEIVTDKKFDIIIMLFIGL 1631

Zfish  1151 NTLSLGMQYCNQPFYITKLSDNLNVIFTVLFTGEMIVKLIAFKAKGYFGDPWNVFDFVIVIGSIV 1215
            |..::.:...:.......:.|.||.||.|:|:.|.::|:.|.:.. ||.:|||:||.|:||.||:
  Fly  1632 NMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYH-YFIEPWNLFDVVVVILSIL 1695

Zfish  1216 DVVLSEVDRTLEASGGLWCLHGCSEVDPMQAIAEAENVKLSITFFRLFRVL---RLIKLLNRSEG 1277
            .:|||::                           .|...:|.|..|:.||.   |:::|:..::|
  Fly  1696 GLVLSDI---------------------------IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1733

Zfish  1278 IRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMFGKIALVDGTEINRNNNFQTFPQAVLLLF 1342
            ||.||:....|..||.::.||:.::.||:|:.||..|..:....|  ||...||:||.|:::|||
  Fly  1734 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFGQSMILLF 1796

Zfish  1343 RVATGEQWPKIMLASMYGKLCD-PKSDYG-PGEEYTCGS-SIAVCYFLSFYMLCAFLVINLFVAI 1404
            :::|...|..::.|.:..:.|| |.:|.| ||   .||| ::.:.:.||:.::...:|||:::|:
  Fly  1797 QMSTSAGWDGVLDAIINEEACDPPDNDKGYPG---NCGSATVGITFLLSYLVISFLIVINMYIAV 1858

Zfish  1405 IMDNFDYLTHD-WSILGPHHLDEFKKIWGEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHHA 1468
            |::|:...|.| ...|.....|.:.:||.::|||.|..|::..:...|..::|||..     |..
  Fly  1859 ILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQI-----HKP 1918

Zfish  1469 ACKRLISMNMPLNSDGTVTFNATLFALVRTALKIKTEGN-FEQANE--ELRA---------IIKS 1521
            ...::|||::|:.....:.....|.||.:.....|  || .|:..|  |:.|         :..:
  Fly  1919 NKYKIISMDIPICRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTEGYEPVSST 1981

Zfish  1522 IWKRTSMKLLDQVIPPIGEDEVTVGKFYATFLIQEHFRKFMQRQEELYGYRPTKKNAD--EIKAG 1584
            :|::              .:|      |...|||..:||...|.|....:.|...:.|  :..||
  Fly  1982 LWRQ--------------REE------YCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAG 2026

Zfish  1585 LRSIEEEAAPELHRAISGDLIAEDEMERAMESGEEGIYRRTGGLFGLNADPFSSEPSSP 1643
                  :.||:  .|..||         |...|:..:.....|.    ||...|..:||
  Fly  2027 ------DPAPD--EATDGD---------APAGGDGSVNGTAEGA----ADADESNVNSP 2064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1sbNP_999891.1 Ion_trans 91..365 CDD:278921 86/295 (29%)
Ion_trans 468..682 CDD:278921 76/222 (34%)
Ion_trans 836..1095 CDD:278921 93/265 (35%)
Ion_trans 1155..1417 CDD:278921 83/268 (31%)
GPHH 1425..1488 CDD:293510 17/62 (27%)
Ca_chan_IQ 1490..1561 CDD:285917 17/82 (21%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 87/296 (29%)
Na_trans_cytopl 515..648 CDD:288761 10/132 (8%)
Ion_trans 835..1028 CDD:278921 68/208 (33%)
Na_trans_assoc 1054..1296 CDD:284034 30/247 (12%)
Ion_trans 1318..1571 CDD:278921 93/266 (35%)
Na_channel_gate 1561..1613 CDD:240441 14/53 (26%)
Ion_trans 1636..1871 CDD:278921 83/267 (31%)
GPHH 1880..1930 CDD:293510 16/54 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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