DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and adra1aa

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_001311383.1 Gene:adra1aa / 798498 ZFINID:ZDB-GENE-030131-2831 Length:485 Species:Danio rerio


Alignment Length:652 Identity:141/652 - (21%)
Similarity:222/652 - (34%) Gaps:293/652 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 LFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWP 352
            |.:|:||    |.||||||.|:||..|.|:.||:||:.:||:||||:|..|:|...:...||.|.
Zfish    47 LAIFIVF----GVLGNILVILSVACHRNLRTVTHYFIVNLAVADLLLSSTVLPFSTVFEMLGRWI 107

  Fly   353 LGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVS 417
            .|..:|:::...|||.|::||:.:|.||:.||:|:..||......|:|...:.:..:||:::.:|
Zfish   108 FGRPFCDVWAAMDVLCCTASIMSLCVISVDRYIGVSYPLQYPSIVTERRALLALIALWVLSITIS 172

  Fly   418 SSITVLG-LVNEKNIMP-EPNICVINNR-AFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFA 479
                 :| |...|...| :.:||.|... .:.:|.:|.:||:|::::::.|.....:.|::.|  
Zfish   173 -----IGPLFGWKEPAPDDESICKITEEPGYAIFSALGSFYLPLVVILSMYCRVYVVARRETR-- 230

  Fly   480 AEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRR 544
                                                                             
Zfish   231 ----------------------------------------------------------------- 230

  Fly   545 SGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSS 609
                                 |.:              ||::|..:.|:                
Zfish   231 ---------------------GLI--------------SGQKTEKSDHA---------------- 244

  Fly   610 PASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTN 674
                  .|.|                   |.||                                
Zfish   245 ------ETVT-------------------LRIH-------------------------------- 252

  Fly   675 VGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPT 739
               .|..||                                                        
Zfish   253 ---RGNMTV-------------------------------------------------------- 258

  Fly   740 ALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVL 804
              ..:|..||:..   ||          ||.|.            .:.|:||.|.||:|...|||
Zfish   259 --SEDEALRNRTH---FA----------LRLLK------------FSREKKAAKTLGIVVGCFVL 296

  Fly   805 CWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNC--K 867
            ||.|||::..|.:..|..:..:.|.....||||.:|.||||||...::.|:.||:.:|...|  |
Zfish   297 CWLPFFLVLPIGSIFPTYRPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAFLSVLGARCLRK 361

  Fly   868 RSGRPLR--YRSVTEGRGALSLCAPSALPLAISFQGAP-LMTPSTANA---TPMS----EFRASC 922
            || .|..  |:|.:...|...:       |.:|.:..| .::||::.|   :|.|    :::|..
Zfish   362 RS-TPSHTLYQSHSPRHGQSQI-------LGLSSRDNPSRLSPSSSIALSRSPSSRDGRDWQAPS 418

  Fly   923 RT 924
            ||
Zfish   419 RT 420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 62/177 (35%)
TM helix 2 321..343 CDD:410628 11/21 (52%)
TM helix 3 359..381 CDD:410628 8/21 (38%)
TM helix 4 404..420 CDD:410628 3/15 (20%)
TM helix 5 443..466 CDD:410628 5/23 (22%)
7tm_GPCRs <779..858 CDD:475119 30/78 (38%)
TM helix 6 792..814 CDD:410628 12/21 (57%)
TM helix 7 826..851 CDD:410628 12/24 (50%)
adra1aaNP_001311383.1 7tm_GPCRs 41..350 CDD:475119 119/572 (21%)
TM helix 1 43..67 CDD:410628 13/23 (57%)
TM helix 2 76..98 CDD:410628 11/21 (52%)
TM helix 3 114..136 CDD:410628 8/21 (38%)
TM helix 4 159..175 CDD:410628 3/20 (15%)
TM helix 5 196..219 CDD:410628 5/22 (23%)
TM helix 6 284..306 CDD:410628 12/21 (57%)
TM helix 7 318..343 CDD:410628 12/24 (50%)

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