Protein Alignment 5-HT2A and htr2b

DIOPT Version :9

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_001038208.1
• Gene: htr2b / 751784
• ZFINID: ZDB-GENE-081022-57
• Length: 443
• Species: Danio rerio
• Alignment Length: 624
• Identity: 160/624 - (25%)
• Similarity: 228/624 - (36%)
• Gaps: 269/624 - (43%)

  Fly   278 LDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMG 342
            :|:..|....|.|.|:.....   |||||.|||:|:|||||.||:||.|||:|||||.|.|||:.
Zfish    10 VDWPSHWAALLILLVIVPTIG---GNILVILAVSLERKLQNATNFFLMSLAVADLLVGLLVMPIA 71

  Fly   343 AIPA-FLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKI 406
            .:.. :...|||....|.|::..|||..::||:|:|.|||.||:.|:.|:......::.....||
Zfish    72 LVTVLYNSTWPLADFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKI 136

  Fly   407 AIVWVMAMMVSSSITVLGLVNEKNIMPEPNI-------CVINN---RAFFVFGSLVAFYIPMLMM 461
            |:||::::.::..|.:.||    .....|||       |:::.   |.|.|:||||||:||:.:|
Zfish   137 ALVWLISIGIAIPIPIKGL----QFFDHPNITFNKNHTCLLSPEGFRDFKVYGSLVAFFIPLAIM 197

  Fly   462 VTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGN 526
            :..|.|||.:|||||                  :.||.:
Zfish   198 MIIYLLTIQVLRKKA------------------YLLRSR-------------------------- 218

  Fly   527 RNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTA 591
                                   |.||          |:.||
Zfish   219 -----------------------AARP----------SISTV----------------------- 227

  Fly   592 HSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNR 656
                       |:...|..||.                       :::.|
Zfish   228 -----------FQQELSVLASP-----------------------EKMVI--------------- 243

  Fly   657 RASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPIL 721
                                               .||....||.|                |:
Zfish   244 -----------------------------------SNGIKRDRTLN----------------PV- 256

  Fly   722 NQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVA 786
                                       |.:...:....|::|       :..||.:|      :.
Zfish   257 ---------------------------NPITGDEVPLRRMST-------IGKRSMQN------LT 281

  Fly   787 TEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPEC--QVPEHVVNTCLWLGYVSSTINPIIYTI 849
            .||:|:||||:||..||:.|.||||.|:....|..|  .:.:.:::...|:|||||.|||::||:
Zfish   282 NEQRASKVLGIVFMLFVVMWCPFFITNVTSVLCERCNGNLVDQLLDIFQWVGYVSSGINPLVYTL 346

  Fly   850 FNRTFRAAFIRLLKCNCKRSGRPLRYR--------SVTE 880
            ||||||.||.|.:.||.|....|...|        ||||
Zfish   347 FNRTFRLAFRRYITCNYKSVRTPKLQRRSKISFRSSVTE 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_4	299..>428	CDD:304433	57/129 (44%)
		7tm_1	302..>477	CDD:278431	81/185 (44%)
htr2b	NP_001038208.1	7tm_1	31..344	CDD:278431	135/557 (24%)
		7tm_4	31..>211	CDD:304433	79/183 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596403
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D408957at33208
OrthoFinder	1	1.000	-	-		FOG0001488
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109927
Panther	1	1.100	-	-	LDO	PTHR24247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4934
SonicParanoid	1	1.000	-	-		X759
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880