DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and Htr6

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_077341.2 Gene:Htr6 / 64354 RGDID:62044 Length:438 Species:Rattus norvegicus


Alignment Length:656 Identity:135/656 - (20%)
Similarity:192/656 - (29%) Gaps:297/656 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 LFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWP 352
            |.:.:|....|..|..:|:|...|    |:|.:|:||.||..:||:|.|.|||...:.|..|.|.
  Rat    33 LCVVIVLTAAANSLLIVLICTQPA----LRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWV 93

  Fly   353 LGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVS 417
            |....|.::...||:.||:|||::|.|||.||:.|.:||..:.|.|.......|...|.:|.:.|
  Rat    94 LARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALAS 158

  Fly   418 SSITVLGLVNE--KNIMPEPNIC-VINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFA 479
            ....:||. :|  |...|.|..| ::.:..|.:..|.|.|::|...:..||...:...||:|   
  Rat   159 FLPLLLGW-HELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQA--- 219

  Fly   480 AEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRR 544
                                                                             
  Rat   220 ----------------------------------------------------------------- 219

  Fly   545 SGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSS 609
                                   |...::..||:|.|                            
  Rat   220 -----------------------VQVASLTTGTAGQA---------------------------- 233

  Fly   610 PASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTN 674
                                             |....||.:..|                    
  Rat   234 ---------------------------------LETLQVPRTPRP-------------------- 245

  Fly   675 VGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPT 739
                                   |..|..|                                   
  Rat   246 -----------------------GMESADS----------------------------------- 252

  Fly   740 ALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVL 804
                               .|:||          :..|.:|         ||:..||::...|.:
  Rat   253 -------------------RRLAT----------KHSRKAL---------KASLTLGILLGMFFV 279

  Fly   805 CWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKC-NCKR 868
            .|.|||:.||..|.| :|..| .:.:...||||.:||:|||||.:|.|.|:.|..|.|.| :|..
  Rat   280 TWLPFFVANIAQAVC-DCISP-GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPP 342

  Fly   869 SGR-----PLRYRSVTEGRGALSLCAPSALPL-----AISFQG--------APLMTPSTANATPM 915
            ..|     |..:.|.:..|..|||.....|||     :.|..|        |.|:.|..|...|.
  Rat   343 EHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPP 407

  Fly   916 SEFRAS 921
            ...||:
  Rat   408 PPTRAT 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 60/177 (34%)
TM helix 2 321..343 CDD:410628 12/21 (57%)
TM helix 3 359..381 CDD:410628 9/21 (43%)
TM helix 4 404..420 CDD:410628 4/15 (27%)
TM helix 5 443..466 CDD:410628 6/22 (27%)
7tm_GPCRs <779..858 CDD:475119 30/78 (38%)
TM helix 6 792..814 CDD:410628 7/21 (33%)
TM helix 7 826..851 CDD:410628 11/24 (46%)
Htr6NP_077341.2 7tmA_5-HT6 29..331 CDD:320182 111/572 (19%)
TM helix 1 29..54 CDD:320182 6/20 (30%)
TM helix 2 61..87 CDD:320182 12/25 (48%)
TM helix 3 99..129 CDD:320182 14/29 (48%)
TM helix 4 141..164 CDD:320182 4/22 (18%)
TM helix 5 185..214 CDD:320182 7/28 (25%)
TM helix 6 261..291 CDD:320182 13/38 (34%)
TM helix 7 299..324 CDD:320182 12/25 (48%)

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