DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and adrb2a

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_001096122.1 Gene:adrb2a / 565838 ZFINID:ZDB-GENE-100414-3 Length:405 Species:Danio rerio


Alignment Length:653 Identity:124/653 - (18%)
Similarity:192/653 - (29%) Gaps:329/653 - (50%)


- Green bases have known domain annotations that are detailed below.


  Fly   247 DMFLPNLTALNTTSTASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVA 311
            |:..||.|..:|.|......:.|..::              |.|.:||       ||::|..|::
Zfish    11 DLICPNNTNASTKSELQMTVLGTLMSI--------------LVLIIVF-------GNVMVITAIS 54

  Fly   312 LDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHM 376
            ..::||||||.|:.|||.|||::.|.|:|.||:...|..|..|...|:.:...|||..::||..:
Zfish    55 RFQRLQNVTNCFITSLACADLVMGLVVIPFGALYIILNTWHFGHFLCDFWTATDVLCVTASIETL 119

  Fly   377 CFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPE------- 434
            |.|::.||:.|.:|...:...||......:.:|||:|          |||:...|..|       
Zfish   120 CVIAMDRYIAITSPFRYQSLLTKNRARFIVLMVWVIA----------GLVSYLPIHMEWWISTDN 174

  Fly   435 PNICVINNR---------AFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRR 490
            ..:|..||.         ::.:..|:::||||:::||..|                   |.:|  
Zfish   175 ETLCCYNNTYCCEFDITYSYAIVSSIISFYIPLVIMVFVY-------------------SRVF-- 218

  Fly   491 LGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLM 555
                     |.:::||:..:...|   :|.:....:||                           
Zfish   219 ---------QEARKQLKKINKTEG---RFHAQKSNSRN--------------------------- 244

  Fly   556 QQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTS 620
                           ::|.|.               ||..|                     ||.
Zfish   245 ---------------QDVANN---------------HSEMR---------------------STK 258

  Fly   621 RSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGA 685
            ::..:.::|                                                        
Zfish   259 KAKFYLKEH-------------------------------------------------------- 267

  Fly   686 TEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNK 750
                                                                             
Zfish   268 ----------------------------------------------------------------- 267

  Fly   751 VRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNII 815
                                                   ||.|.||::...|.|||.|||:||:|
Zfish   268 ---------------------------------------KALKTLGIIMGVFTLCWLPFFVLNVI 293

  Fly   816 FAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCKRSGRPLRYRSVTE 880
                |:..|.........|:||.:|..||:|| ..:..||.||..:|..|  ||    ||.:|..
Zfish   294 ----PKGSVDIWTFRILNWIGYANSAFNPLIY-CGSPDFRYAFKEILCLN--RS----RYPNVRP 347

  Fly   881 GRG 883
            ..|
Zfish   348 NNG 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 59/190 (31%)
TM helix 2 321..343 CDD:410628 11/21 (52%)
TM helix 3 359..381 CDD:410628 7/21 (33%)
TM helix 4 404..420 CDD:410628 4/15 (27%)
TM helix 5 443..466 CDD:410628 7/31 (23%)
7tm_GPCRs <779..858 CDD:475119 27/78 (35%)
TM helix 6 792..814 CDD:410628 11/21 (52%)
TM helix 7 826..851 CDD:410628 8/24 (33%)
adrb2aNP_001096122.1 7tm_GPCRs 31..331 CDD:475119 108/606 (18%)
TM helix 1 31..55 CDD:410628 9/44 (20%)
TM helix 2 64..86 CDD:410628 11/21 (52%)
TM helix 3 102..124 CDD:410628 7/21 (33%)
TM helix 4 147..163 CDD:410628 7/25 (28%)
TM helix 5 192..215 CDD:410628 8/41 (20%)
TM helix 6 270..291 CDD:410628 10/20 (50%)
TM helix 7 300..325 CDD:410628 8/25 (32%)

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