Protein Alignment 5-HT2A and htr7a

DIOPT Version :10

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: XP_021328829.2
• Gene: htr7a / 562111
• ZFINID: ZDB-GENE-130530-666
• Length: 479
• Species: Danio rerio
• Alignment Length: 739
• Identity: 156/739 - (21%)
• Similarity: 241/739 - (32%)
• Gaps: 333/739 - (45%)

  Fly   184 LEREPLREVGSAEESFSNDSLLQAFQIELGAERDGLWSFLNLSELMEP-------DHGFL----- 236
            :..|..||.|::.|:|:.                     :.:||::.|       :.|.:
Zfish    23 MAEERARETGASVETFNG---------------------IMISEVLVPRLFKIAHESGEVAVAAG 66

  Fly   237 -GIMNVTNTSLDMFLPNLTALNTTSTASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGG 300
             |.|::..:|..:.|..:...|.|..|            :..|.|..          |..:..||
Zfish    67 SGSMDMKPSSSPILLEMMEVANGTRCA------------EQILSYGE----------VEKVLIGG 109

  Fly   301 L----------GNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFL-GYWPLG 354
            :          ||:||.::|...:||:..:||.:.|||:|||.|:|.|||..:|...: |.|..|
Zfish   110 VLTMLTLITICGNMLVVISVCFVKKLRQPSNYLIVSLALADLSVALAVMPFVSITDLIGGRWIFG 174

  Fly   355 FTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMV--- 416
            ..:||:::..||:.|::||:.:|.||:.||:||..||....|...          |.||.||
Zfish   175 KFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNG----------WCMAKMVLSV 229

  Fly   417 ---SSSITVLGLVNEKNIMPEPNICVIN-NRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKAR 477
               |:|||:..|......:.:..:|:|: :..:.::.:.|||||||.:|:..|   ..:.|....
Zfish   230 WLLSASITLPPLFGWAQNVNDDRVCLISQDFGYTIYSTAVAFYIPMTVMLVMY---YRIFRAAKL 291

  Fly   478 FAAEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPS 542
            .||:|           ..|..|:..|::::                        |.|:||.|.
Zfish   292 SAAKH-----------TITGFPRVEQEEVE------------------------EDEVEEDGG-- 319

  Fly   543 RRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSS 607
                 :.||.|                                  ||
Zfish   320 -----DGAEEP----------------------------------TG------------------ 327

  Fly   608 SSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYP 672
                                        :|.:.:.::|.
Zfish   328 ----------------------------VDCVTVAIKLQ-------------------------- 338

  Fly   673 TNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVK 737
                                                                         ::|:
Zfish   339 -------------------------------------------------------------REVE 342

  Fly   738 PTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNR-SKRNSLSANAVATEQKATKVLGLVFFT 801
            ..|..|                |:      ||.:..| |.|.|:|  ....||||...||:|...
Zfish   343 ECARLP----------------RI------LRGVGRRCSDRRSIS--IFKREQKAAATLGIVVGA 383

  Fly   802 FVLCWSPFFILNII--FAACPECQ-VPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLK 863
            |.:||.|||:|:..  |....||. :|..|..|.|||||.:|.|||.||..|||..|..:..||.
Zfish   384 FTICWLPFFLLSTARPFICGTECSCIPLWVERTLLWLGYANSLINPFIYAFFNRDLRTTYRSLLS 448

  Fly   864 CNCKRSGRPLRYRSVTEGRGALSL 887
            |         |||::.....|..:
Zfish   449 C---------RYRNINRRLSAAGM 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	64/192 (33%)
		TM helix 2	321..343	CDD:410628	13/21 (62%)
		TM helix 3	359..381	CDD:410628	8/21 (38%)
		TM helix 4	404..420	CDD:410628	6/21 (29%)
		TM helix 5	443..466	CDD:410628	8/22 (36%)
		7tm_GPCRs	<779..858	CDD:475119	37/81 (46%)
		TM helix 6	792..814	CDD:410628	10/21 (48%)
		TM helix 7	826..851	CDD:410628	13/24 (54%)
htr7a	XP_021328829.2	None