DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and drd4-rs

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_001012638.3 Gene:drd4-rs / 503566 ZFINID:ZDB-GENE-051113-172 Length:418 Species:Danio rerio


Alignment Length:601 Identity:147/601 - (24%)
Similarity:234/601 - (38%) Gaps:197/601 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   273 VTKSFLDYSPH-GYDFLFLF----VVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADL 332
            ||.|....:.| ||::|.|.    ::..|.   |||:||||:|..:|.|:..||||:.|||:|||
Zfish     4 VTPSIDPTAAHEGYNYLALICGVPLILIII---LGNVLVCLSVLTERSLKTATNYFIVSLAVADL 65

  Fly   333 LVSLFVMPMGAIPAFL-GYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLG-SRH 395
            |:::.|:|:.....|| |.|.|....|:..:|.||:.|::|||::|.||:.||:.:..||. :|:
Zfish    66 LLAILVLPLYVYSEFLGGIWTLSMYICDALMTMDVMLCTASILNLCAISVDRYIAVVVPLKYNRN 130

  Fly   396 RSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMP--EPNICVINNRAFFVFGSLVAFYIPM 458
            :.:.|...: |...||:::.|:|.: :.||    |.:|  .|::|.:.:..|.|:.|:.:|::|.
Zfish   131 QFSVRQLAL-ITATWVLSLGVASPV-IFGL----NQVPNRNPHVCKLEDNQFVVYSSVCSFFVPC 189

  Fly   459 LMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMG 523
            .:|:..|..   :.|...|:::....|.|.|...||                       :.||:.
Zfish   190 PVMLFLYYW---MFRGLKRWSSGRNRSHLRRPPRGR-----------------------RSLSLR 228

  Fly   524 DGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTT 588
            .|......:|...|.......:|:.|...........||.|..|::..::..|....|.|...||
Zfish   229 LGAALQKEKGRAREKVVYLMPAGLSPTSLTATPTTPISSTSPVTLTTDDLAEGQMPGAESDPMTT 293

  Fly   589 GTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSH 653
                                                                   ::..|..:.:
Zfish   294 -------------------------------------------------------QMDSVSDAEN 303

  Fly   654 PNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQG 718
            |.|                            |||..:|                           
Zfish   304 PER----------------------------ATEDDSG--------------------------- 313

  Fly   719 PILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSAN 783
                :....|.||          :|...:|:                         ||.|.:|..
Zfish   314 ----RENGVGKNH----------RPHTGRRH-------------------------SKSNRVSGR 339

  Fly   784 AVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYT 848
                |:||.|||.:|...|:.||:|||::::..|.|..|.:...:::...|||||:|.:||||||
Zfish   340 ----ERKAMKVLPVVVGVFLACWTPFFVVHVTKALCESCDIGPTLISVVTWLGYVNSAVNPIIYT 400

  Fly   849 IFNRTFRAAFIRLLKC 864
            .||..||..|.:||.|
Zfish   401 AFNVEFRNVFHKLLCC 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 63/178 (35%)
TM helix 2 321..343 CDD:410628 12/21 (57%)
TM helix 3 359..381 CDD:410628 9/21 (43%)
TM helix 4 404..420 CDD:410628 5/15 (33%)
TM helix 5 443..466 CDD:410628 6/22 (27%)
7tm_GPCRs <779..858 CDD:475119 33/78 (42%)
TM helix 6 792..814 CDD:410628 10/21 (48%)
TM helix 7 826..851 CDD:410628 12/24 (50%)
drd4-rsNP_001012638.3 7tmA_D4_dopamine_R 19..410 CDD:320434 137/578 (24%)
TM helix 1 20..46 CDD:320434 11/28 (39%)
TM helix 2 53..79 CDD:320434 13/25 (52%)
TM helix 3 92..122 CDD:320434 13/29 (45%)
TM helix 4 134..157 CDD:320434 6/24 (25%)
TM helix 5 173..202 CDD:320434 7/31 (23%)
TM helix 6 338..368 CDD:320434 13/33 (39%)
TM helix 7 378..403 CDD:320434 12/24 (50%)

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