Protein Alignment 5-HT2A and 5-HT7

DIOPT Version :9

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_001263131.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 627
• Identity: 160/627 - (25%)
• Similarity: 229/627 - (36%)
• Gaps: 225/627 - (35%)

  Fly   252 NLTALNTT--STASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDR 314
            ||...|||  ..:.|..:..|||..:..|  .|....|:.:.::..|....:||:|||:||.:.|
  Fly   129 NLGDSNTTLVPLSDTPLLLEEFAAGEFVL--PPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVR 191

  Fly   315 KLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFI 379
            ||:...||.|.|||::||.|:|.||||..:...|..|..|...|:|:|:.|||.|::|||::|.|
  Fly   192 KLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAI 256

  Fly   380 SLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVS-SSITVLGLVNEKNIMPEPNIC-VINN 442
            |:.||:.|..||....:.|.|...:.:.|||:.|..:| ..:.:||  ||........|| |..|
  Fly   257 SVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILG--NEHEDEEGQPICTVCQN 319

  Fly   443 RAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQHSQQQLQ 507
            .|:.::.:|.:||||:.:|:..|                   .::| |...|..|..:.:|..||
  Fly   320 FAYQIYATLGSFYIPLSVMLFVY-------------------YQIF-RAARRIVLEEKRAQTHLQ 364

  Fly   508 MFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRN 572
              .:.:|:                       |:||     .|...||.....|||
  Fly   365 --QALNGT-----------------------GSPS-----APQAPPLGHTELASS---------- 389

  Fly   573 VVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMD 637
                     |:|:                  ||||....|..:||....||
  Fly   390 ---------GNGQ------------------RHSSVGNTSLTYSTCGGLSS-------------- 413

  Fly   638 RLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSN 702
                                                     ||   ||    ..|:||..|.:.:
  Fly   414 -----------------------------------------GG---GA----LAGHGSGGGVSGS 430

  Fly   703 SSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLN 767
            :.|.|:                                     |...|
  Fly   431 TGLLGS-------------------------------------PHHKK----------------- 441

  Fly   768 LRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTC 832
            |||             .:|.|:||:..||::...|.:||.|||||.:| .......||..:.:..
  Fly   442 LRF-------------QLAKEKKASTTLGIIMSAFTVCWLPFFILALI-RPFETMHVPASLSSLF 492

  Fly   833 LWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCKRSGRPLR 874
            |||||.:|.:|||||...||.||..|..:|...|......:|
  Fly   493 LWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMR 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_4	299..>428	CDD:304433	54/129 (42%)
		7tm_1	302..>477	CDD:278431	68/176 (39%)
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	68/170 (40%)
		7tm_1	179..507	CDD:278431	137/546 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940