Protein Alignment 5-HT2A and Octbeta1R

DIOPT Version :10

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Alignment Length: 709
• Identity: 144/709 - (20%)
• Similarity: 228/709 - (32%)
• Gaps: 317/709 - (44%)

  Fly   187 EPL-REVGSAEESFSNDSLLQAFQIELGAERDGLWSFLNLSELMEPDHGFLGIMNVTNTSLDMFL 250
            ||| .::...|||.|:...|:..       .|||           .|.| ||....:.:|:.:.:
  Fly    32 EPLASKIPVLEESASHARYLKFI-------ADGL-----------IDEG-LGSAVGSGSSIAVSV 77

  Fly   251 PNLTALNT----TSTASTADMATEFAVTKSFLDYSPH-GYDFLFLFVV-FFIFAGGLGNILVCLA 309
            .::.|...    .|..||.|           .|.|.| ...|:..|:: |.|.|..|||:||.::
  Fly    78 EDVVAGQAQDIQASEGSTDD-----------ADGSSHLALVFVKCFIIGFIILAAILGNMLVIVS 131

  Fly   310 VALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSIL 374
            |...|||:.:||||:.|||:||:||:|..|...|.....|.|..|...|:::.:.||...::||:
  Fly   132 VMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIM 196

  Fly   375 HMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLG----LVNEKNIMPEP 435
            |:|.||:.||..|..||......|:|...|.:.:||:...::|......|    ..|.|.:...|
  Fly   197 HLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNP 261

  Fly   436 NICVIN-NRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRP 499
            :||... |:|:.:..|.::|:||.::|::.|                             :.:..
  Fly   262 HICEFKVNKAYAIVSSSMSFWIPGIVMLSMY-----------------------------YRIYQ 297

  Fly   500 QHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRS 564
            :..:|                                              ||.:.:.:.|:.
  Fly   298 EADRQ----------------------------------------------ERLVYRSKVAAL-- 314

  Fly   565 MGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKH 629
                                                                             
  Fly   315 ----------------------------------------------------------------- 314

  Fly   630 GGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNG 694
                 |:::   ||::|.:     |..|.|::|..|
  Fly   315 -----LLEK---HLQISQI-----PKPRPSIQVEQS----------------------------- 337

  Fly   695 SSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFN 759
                             .|:|::
  Fly   338 -----------------TISTMR------------------------------------------ 343

  Fly   760 RVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQV 824
                                       .|:||.:.||::...|::||.|||:..|:.:.|..|..
  Fly   344 ---------------------------RERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCIT 381

  Fly   825 PEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCKRSGRPLRYRSVTEGRG 883
            |..:|....|:||.:|.:|||||..|||.|||||.:.||     |..|..:.....|||
  Fly   382 PRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLK-----SLFPYAFYFCRRGRG 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	61/179 (34%)
		TM helix 2	321..343	CDD:410628	12/21 (57%)
		TM helix 3	359..381	CDD:410628	7/21 (33%)
		TM helix 4	404..420	CDD:410628	4/15 (27%)
		TM helix 5	443..466	CDD:410628	6/22 (27%)
		7tm_GPCRs	<779..858	CDD:475119	31/78 (40%)
		TM helix 6	792..814	CDD:410628	8/21 (38%)
		TM helix 7	826..851	CDD:410628	10/24 (42%)
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	110/575 (19%)
		TM helix 1	109..135	CDD:320194	10/25 (40%)
		TM helix 2	142..168	CDD:320194	14/25 (56%)
		TM helix 3	180..210	CDD:320194	11/29 (38%)
		TM helix 4	222..245	CDD:320194	5/22 (23%)
		TM helix 5	269..298	CDD:320194	8/57 (14%)
		TM helix 6	343..373	CDD:320194	12/98 (12%)
		TM helix 7	383..408	CDD:320194	10/24 (42%)