DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT2A and 5-HT2B

DIOPT Version :9

Sequence 1:	NP_730859.1	Gene:	5-HT2A / 40575	FlyBaseID:	FBgn0087012	Length:	930	Species:	Drosophila melanogaster
Sequence 2:	NP_001262373.1	Gene:	5-HT2B / 41017	FlyBaseID:	FBgn0261929	Length:	947	Species:	Drosophila melanogaster

Alignment Length:	942	Identity:	232/942 - (24%)
Similarity:	336/942 - (35%)	Gaps:	320/942 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 LGAERDG---LWSFLNLSELMEPDHGFLGIMNVTNTSLDMFLPNLTALNTTSTASTADMATEFAV 273
            |||..|.   .||......|.|.|.......|.|:....:   ::...|.|..|:         :
  Fly     9 LGAYNDSGGDDWSSSEHLVLWEEDETQRTTANATSRHNQL---HVARWNATGNAT---------I 61

  Fly   274 TKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFV 338
            :.:|.|......::..|..:..:.....||||||||:|.:|:|||||||||.||||.||:|::.|
  Fly    62 SATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLV 126

  Fly   339 MPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTG 403
            ||:|.:....||:|||...|..::..|||.|::||:|:|.||:.||:.:|.|:......|:|...
  Fly   127 MPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVT 191

  Fly   404 IKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALT 468
            :||..||::::.:|..::::...|..:::.. ..|.|.:..:.:.||:|.||||:.:|:.||.||
  Fly   192 LKIVFVWLLSIAMSLPLSLMYSKNHASVLVN-GTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLT 255

  Fly   469 IPLLRKK-------ARFAAEHP---------ESELFRRLGGRFTLRP----------QHSQQQ-- 505
            :.||.::       .:.||..|         ...|.||...|..|:|          .||...
  Fly   256 VRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTD 320

  Fly   506 ----------------------------LQMF-------------------------SSFSGSNN 517
                                        |..|                         |.||.||:
  Fly   321 TDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNH 385

  Fly   518 KFLSMGDG--------------NRNFNTEGEMEEGGAPSRRSGV--------------EPAERPL 554
            ..|.....              |...:..|...:..:|..|.|.              |.....|
  Fly   386 LQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSL 450

  Fly   555 MQQRTASSRSMGTVS--------FRNVVNGTSGAAGSGRRT------------TGT-----AHSS 594
            ...|....:|.||:|        ::.....:|...|..:|.            |.|     .|:|
  Fly   451 ASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNS 515

  Fly   595 FRFSGAGIFRHSS------------------------------------SSPASSCHSTSTSRSS 623
            .. ..|...||::                                    ...|..||....:..|
  Fly   516 LP-KNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQS 579

  Fly   624 SFWRKHG--GYPNLMDR---------------LAIHLRLSLVPPSSHPN----------RRASVR 661
            .:.:...  ..|...||               .|..:..:....||.|:          .:.|:.
  Fly   580 DYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLT 644

  Fly   662 VTISQPQLGYPTNVGGNGGRTVGAT-------------EVGAGGNG------------------- 694
            .::|....|.|   .|....|||:|             .|.:.|:|
  Fly   645 SSVSAGITGGP---AGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISK 706

  Fly   695 --------SSAGRTSNSSLGG--TSLMKIATIQGPILNQS-----------------QAAG--GN 730
                    ||..|...||.||  |||:...|......|.|                 |.||  |.
  Fly   707 TASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGG 771

  Fly   731 HMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNS--LSANA------VAT 787
                |.:.|...|...||.:.                   :.:...|||  :|.|:      :..
  Fly   772 ----KTRTTTSSPCMLQRQQT-------------------VRSHHSRNSSVISRNSSRHGRIIRL 813

  Fly   788 EQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQ--VPEHVVNTCLWLGYVSSTINPIIYTIF 850
            |||||||||:||||||:.|||||:||::...|.||:  :...|.:...||||.||.:|||.||||
  Fly   814 EQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIF 878

  Fly   851 NRTFRAAFIRLLKCNCKRSGRPLRYRSVTEGR 882
            |:.||.||.::|.|         ||.|.:..|
  Fly   879 NKVFRQAFKKVLLC---------RYSSTSAWR 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_4	299..>428	CDD:304433	57/128 (45%)
5-HT2A	NP_730859.1	7tm_1	302..>477	CDD:278431	74/181 (41%)
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	74/172 (43%)
5-HT2B	NP_001262373.1	7tm_4	90..>238	CDD:304433	61/148 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D408957at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X759
	4	4.020