Protein Alignment 5-HT2A and mAChR-B

DIOPT Version :9

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_649764.1
• Gene: mAChR-B / 40955
• FlyBaseID: FBgn0037546
• Length: 1019
• Species: Drosophila melanogaster
• Alignment Length: 985
• Identity: 163/985 - (16%)
• Similarity: 286/985 - (29%)
• Gaps: 422/985 - (42%)

  Fly   240 NVTNTSLDMFLPNLTA-LNTTSTASTAD------MATEFAVTKSFLDYSPHGYDFLFLFVVFFIF 297
            :|.||:|.:.:.|.:: ..:|.:.|::|      :...||:.::.|        ......:..|.
  Fly    90 DVNNTNLLLAVRNQSSDGGSTMSGSSSDSEILGPVLPPFALWQTIL--------IAICLAICIIL 146

  Fly   298 AGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYV 362
            ..| |||||.||..:||.::..:|||:.|||..|:|:....||...|....|||.||...|::::
  Fly   147 TVG-GNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLKGYWDLGPMLCDLWL 210

  Fly   363 TCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGI--KIAIVWVMAMMVSSSITVLG- 424
            :.|...|..|...:..|::.||..::  :.:::||.:..|.:  .:.|.|::..:: ..|::.|
  Fly   211 SVDYTVCLVSQYTVLLITIDRYCSVK--IAAKYRSWRTRTRVIYMVTITWIIPALL-FFISIFGW 272

  Fly   425 --LVNEKNIMPEPNICVIN-------NRAFFV---FGSLVAFYI--------------------- 456
              ...:::::  |..|.:.       |.|..:   :.:|:..::
  Fly   273 EHFTGKRDLL--PGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQR 335

  Fly   457 PMLMMVTTYA---------------LTIPLLRKKARFAAEHPE-----SELFRRLGGRFTLRP-- 499
            .|..||...|               :...:|:.|...|.:..:     :.:.:||.|.....|
  Fly   336 KMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLA 400

  Fly   500 --------QHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPS----RRSGVEPAER 552
                    ...:|:....:.......|..:..|..::       |...:|:    ..|.|..|::
  Fly   401 VATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKS-------ERSSSPAFDSDEESSVNQAQQ 458

  Fly   553 PLMQQRTASSRSMGTVSFRNVVNGTSGA----AGSGRRTTGTAHSSFRFSGAGIFR-------HS 606
            .:.||:..:.|...::   .:|.|...|    .|.|.....|.:|.   |...:.:       |.
  Fly   459 LITQQKLNNMRKRSSI---GLVFGAQAALLATRGKGNLQKSTTNSK---SIEAMHQYHHHQQHHH 517

  Fly   607 SSSPASSCHSTSTSRS--------SSFWRKHGGYPN------------LMDRLAIHLRL------ 645
            :.||.....|....||        ....:.|...||            .:.::|.|.||
  Fly   518 NQSPLQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAP 582

  Fly   646 ---------------------------SLV----------------------------------- 648
                                       .||
  Fly   583 PTLLNTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELA 647

  Fly   649 ----------------------------------------------------PPSSH-------- 653
                                                                ||.|:
  Fly   648 LTYDLMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQT 712

  Fly   654 ----------------------------------------------------------------- 653
                                                                             
  Fly   713 PSQNQSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVP 777

  Fly   654 -------PNRRA----------------------SVRVTISQPQLGYPTNVGG------------ 677
                   |:|||                      |.:|..|.||.|.|.:..|
  Fly   778 GKLAADCPHRRASSPMETSSKDAILYSPMPPMPLSPKVKTSTPQTGTPQSAAGVTPPVPLERIEE 842

  Fly   678 -------------NGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGG 729
                         ..|.|.....||.||.....|.|..:                       ||.
  Fly   843 RETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKN-----------------------AGD 884

  Fly   730 NHMVQKVKPTALKPEEPQRNKV----RPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQK 790
            :...::.|..|......:|..:    :.||   ::.|.|.:    |....::.|.|.|..   :|
  Fly   885 DDANREEKSLAASRNSSKRAFIHSIGKHFK---SKKALPLI----LGVGGRQKSKSENRA---RK 939

  Fly   791 ATKVLGLVFFTFVLCWSPFFILNIIFAAC--PECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRT 853
            |.:.:..:...||.||:|:.:|.::...|  |.| :.||:.....:|.|.:|.:||..|.:.|:.
  Fly   940 AFRTISFILGCFVACWTPYHVLALVEGFCRHPPC-INEHLYMFSYFLCYANSPMNPFCYALANQQ 1003

  Fly   854 FRAAFIRLLK 863
            |:..|.|:||
  Fly  1004 FKKTFTRILK 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_4	299..>428	CDD:304433	40/133 (30%)
		7tm_1	302..>477	CDD:278431	50/225 (22%)
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	45/195 (23%)
		7tm_4	150..>336	CDD:304433	44/190 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010