Protein Alignment 5-HT2A and drd2l

DIOPT Version :10

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: XP_068070012.2
• Gene: drd2l / 378718
• ZFINID: ZDB-GENE-030910-1
• Length: 450
• Species: Danio rerio
• Alignment Length: 636
• Identity: 152/636 - (23%)
• Similarity: 247/636 - (38%)
• Gaps: 207/636 - (32%)

  Fly   238 IMNVTNTSLDMFLPNLTALNTTSTASTADMATEFAVTKSFLDYSPH----GYDFLFLFVVFFIFA 298
            ||.|.|.:.::          |.|||.:. |...::.:|....||.    .|:|..:.:|..||.
Zfish    13 IMPVLNVTEEL----------TITASPSS-AVFLSLHQSNCSVSPSPSSPPYNFYAVLLVLLIFC 66

  Fly   299 GGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVT 363
            ...||:|||:||:.::.||..|||.:.|||::|||::..|||.|.....:|.|......|::.:|
Zfish    67 VVFGNVLVCVAVSREKALQTTTNYLIVSLAVSDLLLATLVMPWGVYLEVVGEWRFSRIHCDVLLT 131

  Fly   364 CDVLACSSSILHMCFISLGRYMGIRNPL--GSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLV 426
            .||:.|::|||::|.||:.||..:..||  .:|: |::|...:.||:||.::..:|..: :.||.
Zfish   132 LDVMMCTASILNLCAISIDRYTAVAMPLLYNTRY-SSRRRVALMIAVVWFLSFAISCPL-LFGLN 194

  Fly   427 NEKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRL 491
            |..:  .|...|...:.||.|:.|:.:||:|.::.:..|.....:||::
Zfish   195 NTAS--QEGRDCSFADPAFVVYSSVASFYVPFIVTLLVYVQICVVLRRR---------------- 241

  Fly   492 GGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRR--SGVEPAERPL 554
             ||.|                                           ||:||  :..|||:
Zfish   242 -GRRT-------------------------------------------APTRRRAANTEPAD--- 259

  Fly   555 MQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTST 619
             .||:..::.                                         :.......|
Zfish   260 -AQRSRKNKC-----------------------------------------THPEDVKLC----- 277

  Fly   620 SRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVG 684
                                    .|.|.||::.|.|:   :||:.:..:.:|.
Zfish   278 ------------------------TLILKPPAAAPQRK---KVTLVKEAVVHPL----------- 304

  Fly   685 ATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTA-LKPEEPQR 748
            |.|...   ..||.|..                    .|:|.:|...:...|.|.| .....|:|
Zfish   305 AVEPVC---SLSADREQ--------------------TQTQPSGRAKLSLSVAPCAGQSGPGPRR 346

  Fly   749 NKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILN 813
            :.::.........|.         ....|..||..   .|:|||::|.:|...|::||.|||:.:
Zfish   347 DTLQEKTHTEKHAAA---------KERVRGRLSQQ---KERKATQMLAIVLGVFIICWLPFFLTH 399

  Fly   814 IIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKC 864
            ::.|.|..|.:...:.:...||||::|.:||:|||.||..||.|||::|.|
Zfish   400 VLKAHCGSCCISPSLYSAVTWLGYLNSAVNPVIYTTFNIEFRKAFIKILHC 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	60/176 (34%)
		TM helix 2	321..343	CDD:410628	11/21 (52%)
		TM helix 3	359..381	CDD:410628	9/21 (43%)
		TM helix 4	404..420	CDD:410628	5/15 (33%)
		TM helix 5	443..466	CDD:410628	7/22 (32%)
		7tm_GPCRs	<779..858	CDD:475119	31/78 (40%)
		TM helix 6	792..814	CDD:410628	9/21 (43%)
		TM helix 7	826..851	CDD:410628	10/24 (42%)
drd2l	XP_068070012.2	None