Protein Alignment 5-HT2A and 5-HT1B

DIOPT Version :10

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 729
• Identity: 182/729 - (24%)
• Similarity: 301/729 - (41%)
• Gaps: 182/729 - (24%)

  Fly   189 LREVGSAEESFSNDSLLQAFQIELGA---------ERDGLWSFLNLSELMEPDHGFLGIMNVTNT 244
            |:.|.:|..:..:|......:|||.|         |.:|     ||::|::           |.:
  Fly     2 LKTVTTAMAAGDDDVPASILEIELPAILLNESLFIELNG-----NLTQLVD-----------TTS 50

  Fly   245 SLDMFLPNLTALNTTSTASTADM--------ATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGGL 301
            :|...:.| .::|....::|.|:        |.||.:....:..:.    .|.|.::..|    :
  Fly    51 NLSQIVWN-RSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAV----VLGLMILVTI----I 106

  Fly   302 GNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDV 366
            ||:.|..|:.|:|.||||.||.:.|||:|||.|:..|||:||:......|.||...|:|:.:|||
  Fly   107 GNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDV 171

  Fly   367 LACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVS-------SSITVLG 424
            |.|::||||:..|:..||..:.| :...:..|.|...:.|..||..|::||       .....:.
  Fly   172 LCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMK 235

  Fly   425 LVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFR 489
            .:.|::.|...::      .:.:|.:...||:|:|:::..|.....:.||:.:           |
  Fly   236 RIEEQHCMVSQDV------GYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQ-----------R 283

  Fly   490 RLGGRFTLRPQHSQ-----QQLQMFSSFSGSNNKFLSMG-----DGNRNFNTEGEMEEGGAPSRR 544
            |....|.:....:.     ::|:...|...:..|.|..|     ||:   .|.|:::
  Fly   284 RAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGD---GTGGQLQ-------- 337

  Fly   545 SGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRH---- 605
                  .|...:.|....|:..|.   |||.|:.||.     ....|..:..|:...|.|.
  Fly   338 ------RRTRKRMRICFGRNTNTA---NVVAGSEGAV-----ARSMAAIAVDFASLAITREETEF 388

  Fly   606 SSSSPASSCHS----TSTSRSSSFWRKHGGYP--NLMDRLAIHLRLSLVPPSSHPNRRASVRVTI 664
            |:|:..:..|:    |:.|..:..:|......  .|..::|...:..|:  :||.|....:..:|
  Fly   389 STSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLI--ASHLNAITPLAQSI 451

  Fly   665 SQPQLG-----YPTNVGGNGGRTVGATEVGAGGNGS------SAGRTSNSSLGGTSLMKIATIQG 718
            :...:|     .|:....:|..||.....|..|:||      :.|:.:...|||.    :|:|..
  Fly   452 AMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGV----LASIAN 512

  Fly   719 PILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSAN 783
            |           |  ||:                                     ..:|..|.|.
  Fly   513 P-----------H--QKL-------------------------------------AKRRQLLEAK 527

  Fly   784 AVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYT 848
               .|:||.:.|.::...||:||.|||::.:..:.|.||::...|.:..|||||.:||:||:|||
  Fly   528 ---RERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYT 589

  Fly   849 IFNRTFRAAFIRLL 862
            |||..||.||.|:|
  Fly   590 IFNPEFRRAFKRIL 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	58/181 (32%)
		TM helix 2	321..343	CDD:410628	12/21 (57%)
		TM helix 3	359..381	CDD:410628	11/21 (52%)
		TM helix 4	404..420	CDD:410628	6/22 (27%)
		TM helix 5	443..466	CDD:410628	5/22 (23%)
		7tm_GPCRs	<779..858	CDD:475119	34/78 (44%)
		TM helix 6	792..814	CDD:410628	8/21 (38%)
		TM helix 7	826..851	CDD:410628	14/24 (58%)
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	7/33 (21%)
		TM helix 2	125..151	CDD:320454	14/25 (56%)
		TM helix 3	163..193	CDD:320454	14/29 (48%)
		TM helix 4	204..226	CDD:320454	7/21 (33%)
		TM helix 5	247..276	CDD:320454	6/34 (18%)
		7tm_GPCRs	<525..599	CDD:475119	33/76 (43%)
		TM helix 6	533..555	CDD:410628	8/21 (38%)
		TM helix 7	567..592	CDD:410628	14/24 (58%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	65/221 (29%)