DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and HTR1E

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_000856.1 Gene:HTR1E / 3354 HGNCID:5291 Length:365 Species:Homo sapiens


Alignment Length:612 Identity:120/612 - (19%)
Similarity:199/612 - (32%) Gaps:254/612 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   256 LNTTSTASTADMATE-FAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNV 319
            :|.|:..:.|.||.. ..:|:..|         :.:.:|.......|.|:.|.:|:...:||...
Human     1 MNITNCTTEASMAIRPKTITEKML---------ICMTLVVITTLTTLLNLAVIMAIGTTKKLHQP 56

  Fly   320 TNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRY 384
            .||.:.|||:.||||::.|||:..|...:..|.||:..|.::::.|:..|:.||||:|.|:|.||
Human    57 ANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRY 121

  Fly   385 MGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPNICVI--NNRAFFV 447
            ..|.|.:....:.|.:...:.|..||.:::.:  |:..|...:.:.:.|.|:.|.|  ::..:.:
Human   122 WAITNAIEYARKRTAKRAALMILTVWTISIFI--SMPPLFWRSHRRLSPPPSQCTIQHDHVIYTI 184

  Fly   448 FGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQHSQQQLQMFSSF 512
            :.:|.|||||:.:::..|            :...|....|:::.|                    
Human   185 YSTLGAFYIPLTLILILY------------YRIYHAAKSLYQKRG-------------------- 217

  Fly   513 SGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGT 577
                                                            |||.:            
Human   218 ------------------------------------------------SSRHL------------ 222

  Fly   578 SGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIH 642
                 |.|.|                  .|.:..:||..|.|...|.|        :..|     
Human   223 -----SNRST------------------DSQNSFASCKLTQTFCVSDF--------STSD----- 251

  Fly   643 LRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGG 707
                  |.:......||:|:......|.:|                                   
Human   252 ------PTTEFEKFHASIRIPPFDNDLDHP----------------------------------- 275

  Fly   708 TSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLN 772
                                                                             
Human   276 ----------------------------------------------------------------- 275

  Fly   773 NRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGY 837
              .:|..:|:   ..|:||.::|||:...|:|.|.||||..:| .......|...|.:...||||
Human   276 --GERQQISS---TRERKAARILGLILGAFILSWLPFFIKELI-VGLSIYTVSSEVADFLTWLGY 334

  Fly   838 VSSTINPIIYTIFNRTFRAAFIRLLKC 864
            |:|.|||::||.||..|:.||.:|::|
Human   335 VNSLINPLLYTSFNEDFKLAFKKLIRC 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 53/176 (30%)
TM helix 2 321..343 CDD:410628 12/21 (57%)
TM helix 3 359..381 CDD:410628 8/21 (38%)
TM helix 4 404..420 CDD:410628 3/15 (20%)
TM helix 5 443..466 CDD:410628 6/22 (27%)
7tm_GPCRs <779..858 CDD:475119 31/78 (40%)
TM helix 6 792..814 CDD:410628 10/21 (48%)
TM helix 7 826..851 CDD:410628 12/24 (50%)
HTR1ENP_000856.1 7tmA_5-HT1E 23..355 CDD:320457 110/582 (19%)
TM helix 1 24..50 CDD:320457 6/34 (18%)
TM helix 2 57..83 CDD:320457 13/25 (52%)
TM helix 3 95..125 CDD:320457 12/29 (41%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 119..121 0/1 (0%)
TM helix 4 137..159 CDD:320457 4/23 (17%)
TM helix 5 179..208 CDD:320457 7/40 (18%)
TM helix 6 284..314 CDD:320457 14/30 (47%)
TM helix 7 323..348 CDD:320457 12/24 (50%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 340..344 2/3 (67%)

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