Protein Alignment 5-HT2A and Dop2R

DIOPT Version :9

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Alignment Length: 1017
• Identity: 244/1017 - (23%)
• Similarity: 376/1017 - (36%)
• Gaps: 322/1017 - (31%)

  Fly    12 STGTSETATATAAVASASASDTA-----ATFTLRHFNCRLE----------EADWPGPRQPFIDC 61
            :..|:.|.:||.:.|:||.|.||     ||:...|.....:          :|...||..|
  Fly    42 TAATAATTSATLSTAAASTSTTAAPSAGATWINHHLAVEADSSQPANGSDAQAGVEGPTMP---- 102

  Fly    62 EGSHTNSTSYTPSSLPTSKNLIEGPNNTFQCARQA-IDEAEHNAFYSCDGESPLS--ENCTLRLK 123
                   ..|.|        |.|......:.|..| ||:.......|...|:.:.  ||.|
  Fly   103 -------AGYLP--------LYEDVETAAEDAGYALIDDISEWLLGSVGSEAAVGGPENST---- 148

  Fly   124 ARLLRWPYEAYEHIRLAINGA------LSDYASDKLSDSSSCDEGGMVLQCKLGQAHELLLCHLQ 182
                          .||:.||      |....|.:.:.|:|..|.|           |.....|:
  Fly   149 --------------NLAVTGANGTLAWLEALNSTQPAQSNSSAEDG-----------ERGRYSLR 188

  Fly   183 QLEREPLREVGSAEESFSNDSLLQAFQIELGAERDGLWSFLNLSELMEPDHGFLG------IMNV 241
            ....:.|...|:|......|:.:..  |:.|.|.    :..|::: .|.|:|.||      ::..
  Fly   189 SFVEQQLAGGGAAGAGDGGDAGIAL--IDSGEEA----ALDNVAD-AETDYGMLGGFGDAELLQR 246

  Fly   242 TNTSLDMFLPNLTALNTTS--------------TASTA----------DMATEFAVTKSFLDYSP 282
            |.|.....|.|.||.:|||              .|.||          ..:|...:.::|.||.|
  Fly   247 TATVARETLGNRTAPSTTSYDGGGSGDVGVAGGLAGTAGGGVGGAGGSGGSTFMLLLENFNDYFP 311

  Fly   283 H--------------------------------------GYD----------------------- 286
            :                                      ||.
  Fly   312 NYNGSTVSGTSTIAPGVAITGSRGSGLLLEQNLTGLYLDGYRLNCTNETLNLTDSCGELRVVDHN 376

  Fly   287 ----FLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAF 347
                .|.||.:..:|    |||||.|:|..:|.||.|||||:.|||||||||::.|||.......
  Fly   377 YWALILILFPILTLF----GNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLV 437

  Fly   348 LGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLG-SRHRSTKRLTGIKIAIVWV 411
            .|.|.|....|:.|:..||:..:|||.::..||:.||:.:..|:. ::|::::|:. :.|.:||.
  Fly   438 NGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVC-LTILLVWA 501

  Fly   412 MAMMVSSSITVLGLVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKA 476
            ::..:.|.| ||||.|..|  .||::|...|..|.::.||.:||||.::||..|......||.:|
  Fly   502 ISAAIGSPI-VLGLNNTPN--REPDVCAFYNADFILYSSLSSFYIPCIIMVFLYWNIFKALRSRA 563

  Fly   477 R--FAAEHPE-SELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEG 538
            |  .||..|. |||                                           |.|.:.|.
  Fly   564 RKQRAARKPHLSEL-------------------------------------------TGGSVIEN 585

  Fly   539 GAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIF 603
            .|.:||.    ||..|...|.| ||.:...:      .|:.|:||.....
  Fly   586 IAQTRRL----AETALDSSRHA-SRILPDEA------ATNTASGSNEEED--------------- 624

  Fly   604 RHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQ 668
            .::.|.....||.....:|:.|                 :..::|..:.:    :.|....:|||
  Fly   625 ENAISPDIDDCHVIVNDKSTEF-----------------MLATVVEETGN----SVVAQITTQPQ 668

  Fly   669 LGYPTNVGGNGGRTVGATEV---------GAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQS 724
            | ...:..||......|:.|         .:....:||...|:.|...:.|...||:|...::..
  Fly   669 L-VVADPNGNHDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQ 732

  Fly   725 QAAGGNHMVQKVKP-----------TALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRN 778
            :...|:...::.:|           .|:||....|..|:.........:|.:...:..:.:.|:|
  Fly   733 RRPTGDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKN 797

  Fly   779 SLSA-----------------NAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAAC----PEC 822
            |.::                 ::...|:||||.|.:|...|:.||.|||..||:.|.|    .:|
  Fly   798 SQASRFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDC 862

  Fly   823 Q--VPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLL 862
            :  :..:::.|  ||||::|.:||:||||||..||.||.:::
  Fly   863 RPGLTAYMMTT--WLGYINSFVNPVIYTIFNPEFRKAFKKIM 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_4	299..>428	CDD:304433	53/129 (41%)
		7tm_1	302..>477	CDD:278431	71/175 (41%)
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	76/196 (39%)
		TM helix 1	377..403	CDD:320181	11/29 (38%)
		TM helix 2	410..436	CDD:320181	16/25 (64%)
		TM helix 3	448..478	CDD:320181	11/29 (38%)
		TM helix 4	490..513	CDD:320181	7/24 (29%)
		TM helix 5	529..558	CDD:320181	11/28 (39%)
		7tm_GPCRs	<822..898	CDD:333717	34/77 (44%)
		TM helix 6	825..850	CDD:320095	12/24 (50%)
		TM helix 7	866..891	CDD:320095	12/26 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910