DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and Drd3

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_058836.1 Gene:Drd3 / 29238 RGDID:2521 Length:446 Species:Rattus norvegicus


Alignment Length:636 Identity:163/636 - (25%)
Similarity:241/636 - (37%) Gaps:223/636 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 TALNTTSTASTADMATEFAVTKSFLDYSPH-----GYDFLFLFVVFFIFAGGLGNILVCLAVALD 313
            |.||:|..|..:.     .|.::    .||     .|..|.|.::|       ||.|||.||..:
  Rat     9 THLNSTCGAENST-----GVNRA----RPHAYYALSYCALILAIIF-------GNGLVCAAVLRE 57

  Fly   314 RKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFL----GYWPLGFTWCNIYVTCDVLACSSSIL 374
            |.||..|||.:.|||:|||||:..|||.   ..:|    |.|......|:::||.||:.|::|||
  Rat    58 RALQTTTNYLVVSLAVADLLVATLVMPW---VVYLEVTGGVWNFSRICCDVFVTLDVMMCTASIL 119

  Fly   375 HMCFISLGRYMGIRNPLGSRH---RSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPN 436
            ::|.||:.||..:..|:..:|   :|:.|...:.|..|||:|..||..: :.|.    |...:|:
  Rat   120 NLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPL-LFGF----NTTGDPS 179

  Fly   437 ICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQH 501
            ||.|:|..|.::.|:|:||:|..:.|..||....:||::.|      :..|.|:.....::||..
  Rat   180 ICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQR------KRILTRQNSQCISIRPGF 238

  Fly   502 SQQ----QLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASS 562
            .||    :|.....|| ...:|||        :..|:||.         :|..:.|         
  Rat   239 PQQSSCLRLHPIRQFS-IRARFLS--------DATGQMEH---------IEDKQYP--------- 276

  Fly   563 RSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFWR 627
                                                             ..|             
  Rat   277 -------------------------------------------------QKC------------- 279

  Fly   628 KHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGG 692
                    .|.|..||:    |||.                           |:|.|        
  Rat   280 --------QDPLLSHLQ----PPSP---------------------------GQTHG-------- 297

  Fly   693 NGSSAGRTSNSSLGGTSLMKIATI-QGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKF 756
                            .|.:..:| |...|......||         ..:.|.|..||.:.|   
  Rat   298 ----------------GLKRYYSICQDTALRHPSLEGG---------AGMSPVERTRNSLSP--- 334

  Fly   757 AFNRVATPTLNL--RFLNNRSKRNSLSANAV------ATEQKATKVLGLVFFTFVLCWSPFFILN 813
                ...|.|:|  |.|:|.....||....:      ..|:|||:::.:|...|::||.|||:.:
  Rat   335 ----TMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTH 395

  Fly   814 IIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKC 864
            ::...|..|.|...:.....|||||:|.:||:|||.||..||.||:::|.|
  Rat   396 VLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 68/181 (38%)
TM helix 2 321..343 CDD:410628 13/21 (62%)
TM helix 3 359..381 CDD:410628 10/21 (48%)
TM helix 4 404..420 CDD:410628 7/15 (47%)
TM helix 5 443..466 CDD:410628 7/22 (32%)
7tm_GPCRs <779..858 CDD:475119 31/84 (37%)
TM helix 6 792..814 CDD:410628 8/21 (38%)
TM helix 7 826..851 CDD:410628 11/24 (46%)
Drd3NP_058836.1 7tmA_D3_dopamine_R 30..440 CDD:320436 151/598 (25%)
TM helix 1 31..57 CDD:320436 11/32 (34%)
TM helix 2 64..87 CDD:320436 14/25 (56%)
TM helix 3 103..133 CDD:320436 14/29 (48%)
TM helix 4 150..168 CDD:320436 7/17 (41%)
TM helix 5 185..210 CDD:320436 9/24 (38%)
TM helix 6 368..398 CDD:320436 11/29 (38%)
TM helix 7 408..433 CDD:320436 11/24 (46%)

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