DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and ser-3

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_491954.1 Gene:ser-3 / 259744 WormBaseID:WBGene00004778 Length:610 Species:Caenorhabditis elegans


Alignment Length:649 Identity:167/649 - (25%)
Similarity:261/649 - (40%) Gaps:158/649 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   257 NTTSTASTADMATEFAVTKSFLDYS--PHGYDFLFLFVVF-----FIFAGGLGNILVCLAVALDR 314
            |||:|.......||.:...||.::|  |....|..:|.:.     .:....|||.||..||.|.|
 Worm    23 NTTTTTLGFTPITEESPNCSFYEWSRNPSHAQFFRIFSIISVLTVLVVVVVLGNALVIAAVLLRR 87

  Fly   315 KLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLG-YWPLGFTWCNIYVTCDVLACSSSILHMCF 378
            :|::.|...:.|||:|||||...::|.......|. ||..|.|||.|::|.|:..|::||.::..
 Worm    88 RLRSATGLLILSLALADLLVGTVILPFSIANEVLDQYWIFGETWCTIWLTLDIWMCTASIYNLVA 152

  Fly   379 ISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMV-SSSITVLGLVNEKNIMPEPNICVINN 442
            ||:.||:.|..||......||......:||||:.:.:: |.|..:...:.:|.   .|..|...|
 Worm   153 ISIDRYIAIIKPLNYPMLVTKFRARCTVAIVWIGSFLICSPSFFLASSIKDKE---TPCRCTPAN 214

  Fly   443 --RAFFVFGSLVAFYIPMLMMVTTY-------------------ALTIPLLRKKARFAAEHPESE 486
              |.:.||.:..:|||||:::|..|                   ::|....:|      ::|:|.
 Worm   215 AGRVYVVFSASSSFYIPMIIVVFVYFRIYVAARAATKSIYSGMMSVTAAANKK------QNPKSY 273

  Fly   487 LFRRLGGRFTLRPQH----SQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSG- 546
            |.           .|    ::..|.|.....||:  .::....|:.:||          .|::| 
 Worm   274 LL-----------NHPDVINKDSLPMLRVHRGSS--VVAQITPNKPYNT----------CRQNGN 315

  Fly   547 -VEPAERPLMQQRTAS--SRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSS 608
             ::.......|...|:  :|.....|.:.:||  .||.|:.::..         .||...||...
 Worm   316 SIDATANGTSQITAAATKARKFANDSAKTLVN--RGAVGATQQAP---------IGARFKRHGRD 369

  Fly   609 SPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPT 673
            |.:|......|:..|:...|.|.     :.|.     ||:     .|.|:|  .|.|..:....|
 Worm   370 SESSVDSMNGTNSYSATPHKSGN-----EELG-----SLI-----ENSRSS--STDSNEKTEQLT 417

  Fly   674 NVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQK--V 736
            |      :|.....:....|........:.||...|..|         ::|.|:..||::::  .
 Worm   418 N------QTDDNFSMSNNNNNGDEKEAFDESLLSESKKK---------SKSLASKFNHLMRRGQK 467

  Fly   737 KPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFT 801
            |.||...|                               ||.||       |.||.|.:.:|...
 Worm   468 KRTAGAYE-------------------------------KRLSL-------EIKAAKTVAIVTGC 494

  Fly   802 FVLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCN 865
            |:.||..|.::..:     |.::.:.|.:...||||::|.:||:|||:|||.||..|.|||.|:
 Worm   495 FIFCWLGFALVYGL-----EIKLNDVVWSIVFWLGYLNSALNPVIYTVFNREFRICFKRLLTCH 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 63/197 (32%)
TM helix 2 321..343 CDD:410628 9/21 (43%)
TM helix 3 359..381 CDD:410628 7/21 (33%)
TM helix 4 404..420 CDD:410628 5/16 (31%)
TM helix 5 443..466 CDD:410628 10/41 (24%)
7tm_GPCRs <779..858 CDD:475119 28/78 (36%)
TM helix 6 792..814 CDD:410628 6/21 (29%)
TM helix 7 826..851 CDD:410628 11/24 (46%)
ser-3NP_491954.1 7tmA_Octopamine_R 80..>252 CDD:320191 57/174 (33%)
TM helix 2 93..119 CDD:320191 10/25 (40%)
TM helix 3 132..162 CDD:320191 11/29 (38%)
TM helix 4 174..197 CDD:320191 6/22 (27%)
TM helix 5 216..245 CDD:320191 10/28 (36%)
7tm_GPCRs <479..546 CDD:475119 28/78 (36%)
TM helix 6 485..507 CDD:410628 6/21 (29%)
TM helix 7 514..539 CDD:410628 11/24 (46%)

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