DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and Hrh2

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_001399940.1 Gene:Hrh2 / 25461 RGDID:2831 Length:402 Species:Rattus norvegicus


Alignment Length:642 Identity:123/642 - (19%)
Similarity:181/642 - (28%) Gaps:329/642 - (51%)


- Green bases have known domain annotations that are detailed below.


  Fly   302 GNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDV 366
            ||::|||||:|:|:|:::||.|:.|||..|||:.|.|:|..||......|..|..:||||.:.||
  Rat    35 GNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFKWSFGHVFCNIYTSLDV 99

  Fly   367 LACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAI----VWVMAMMVSSSITVLGLVN 427
            :.|::|||::..|||.||..:.:||    |....:|.:::||    :||:::.:|.....||. |
  Rat   100 MLCTASILNLFMISLDRYCAVTDPL----RYPVLVTPVRVAISLVFIWVISITLSFLSIHLGW-N 159

  Fly   428 EKNIMPEPN---ICVIN-NRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELF 488
            .:|.....|   .|.:. |..:.:...||.||:|:|:|..||.....:.|::|            
  Rat   160 SRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQA------------ 212

  Fly   489 RRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERP 553
            :|:                                                              
  Rat   213 KRI-------------------------------------------------------------- 215

  Fly   554 LMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTS 618
                                                              .|.||          
  Rat   216 --------------------------------------------------NHISS---------- 220

  Fly   619 TSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTV 683
                   |                                                         
  Rat   221 -------W--------------------------------------------------------- 221

  Fly   684 GATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQR 748
                                        |.|||:                               
  Rat   222 ----------------------------KAATIR------------------------------- 227

  Fly   749 NKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILN 813
                                                   |.|||..|..|...|::||.|:|...
  Rat   228 ---------------------------------------EHKATVTLAAVMGAFIICWFPYFTAF 253

  Fly   814 IIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKC---------NCKRS 869
            :......:..:.|.|....|||||.:|.:|||:|...||.||.|:.:|..|         ...|.
  Rat   254 VYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRL 318

  Fly   870 GRPLRYRSVT-EGRGALSLCAPSALPLAIS-FQGAPLMTPSTANATPMSEFRASCRT 924
            ...|..||.: |||.      ....||.:. :.|..|..|   ...|:.:...||.|
  Rat   319 NNSLLPRSQSREGRW------QEEKPLKLQVWSGTELTHP---QGNPIRKTTLSCTT 366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 66/178 (37%)
TM helix 2 321..343 CDD:410628 11/21 (52%)
TM helix 3 359..381 CDD:410628 10/21 (48%)
TM helix 4 404..420 CDD:410628 5/19 (26%)
TM helix 5 443..466 CDD:410628 8/22 (36%)
7tm_GPCRs <779..858 CDD:475119 27/78 (35%)
TM helix 6 792..814 CDD:410628 8/21 (38%)
TM helix 7 826..851 CDD:410628 12/24 (50%)
Hrh2NP_001399940.1 7tmA_Histamine_H2R 19..298 CDD:320179 104/563 (18%)
TM helix 1 20..46 CDD:320179 7/10 (70%)
TM helix 2 53..80 CDD:320179 14/26 (54%)
TM helix 3 91..121 CDD:320179 15/29 (52%)
TM helix 4 133..153 CDD:320179 5/19 (26%)
TM helix 5 178..208 CDD:320179 10/29 (34%)
TM helix 6 226..256 CDD:320179 12/99 (12%)
TM helix 7 266..291 CDD:320179 12/24 (50%)

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