DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT2A and Htr2c

DIOPT Version :9

Sequence 1:	NP_730859.1	Gene:	5-HT2A / 40575	FlyBaseID:	FBgn0087012	Length:	930	Species:	Drosophila melanogaster
Sequence 2:	NP_036897.2	Gene:	Htr2c / 25187	RGDID:	2848	Length:	460	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	155/632 - (24%)
Similarity:	240/632 - (37%)	Gaps:	266/632 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 DMFLPNLTALNTTSTASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVA 311
            |:.:..:.|: .|.|.:::|....|    .|.| ....:..|.:.|:..:..|  |||||.:||:
  Rat    24 DISISPVAAI-VTDTFNSSDGGRLF----QFPD-GVQNWPALSIVVIIIMTIG--GNILVIMAVS 80

  Fly   312 LDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGY-WPLGFTWCNIYVTCDVLACSSSILH 375
            :::||.|.|||||.||||||:||.|.|||:..:.....| |||....|.::::.|||..::||:|
  Rat    81 MEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMH 145

  Fly   376 MCFISLGRYMGIRNPL-GSRHRS-TKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPNIC 438
            :|.|||.||:.||||: .||..| ||.:  :||||||.:::.||..|.|:||.:|..:......|
  Rat   146 LCAISLDRYVAIRNPIEHSRFNSRTKAI--MKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTC 208

  Fly   439 VINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQHSQ 503
            |:|:..|.:.||.|||:||:.:||.||.|||.:||::.                  ..|...|::
  Rat   209 VLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQT------------------LMLLRGHTE 255

  Fly   504 QQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTV 568
            ::|
  Rat   256 EEL-------------------------------------------------------------- 258

  Fly   569 SFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYP 633
                                  |:.|..|             .:.|           .:|:||..
  Rat   259 ----------------------ANMSLNF-------------LNCC-----------CKKNGGEE 277

  Fly   634 NLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAG 698
            .             ..|:.:|:
  Rat   278 E-------------NAPNPNPD------------------------------------------- 286

  Fly   699 RTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVAT 763
                                                         ::|:|.|
  Rat   287 ---------------------------------------------QKPRRKK------------- 293

  Fly   764 PTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPEC---QVP 825
                      :.||...:..|:..|:||:||||:|||.|::.|.||||.||:...|.:.   ::.
  Rat   294 ----------KEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLM 348

  Fly   826 EHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCKRSGRP 872
            |.::|..:|:|||.|.|||::||:||:.:|.||.:.|:|:.|...:|
  Rat   349 EKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKP 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_4	299..>428	CDD:304433	66/131 (50%)
5-HT2A	NP_730859.1	7tm_1	302..>477	CDD:278431	86/177 (49%)
Htr2c	NP_036897.2	7tm_4	64..>248	CDD:304433	87/205 (42%)
		7tm_1	71..370	CDD:278431	133/550 (24%)
		Agonist binding. /evidence=ECO:0000250	135..140		3/4 (75%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	152..154		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..301		7/148 (5%)
		Agonist binding. /evidence=ECO:0000250	326..330		2/3 (67%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	366..370		2/3 (67%)
		PDZ-binding	458..460
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BHN1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D408957at33208
OrthoFinder	1	1.000	-	-		FOG0001488
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X759
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820