DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and Drd2

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_036679.1 Gene:Drd2 / 24318 RGDID:2520 Length:444 Species:Rattus norvegicus


Alignment Length:599 Identity:153/599 - (25%)
Similarity:237/599 - (39%) Gaps:202/599 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   282 PHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPA 346
            || |::..:.:...||....||:|||:||:.::.||..|||.:.|||:|||||:..|||......
  Rat    32 PH-YNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLE 95

  Fly   347 FLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPL--GSRHRSTKRLTGIKIAIV 409
            .:|.|......|:|:||.||:.|::|||::|.||:.||..:..|:  .:|:.|.:|:| :.||||
  Rat    96 VVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVT-VMIAIV 159

  Fly   410 WVMAMMVSSSITVLGLVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRK 474
            ||::..:|..: :.||.|     .:.|.|:|.|.||.|:.|:|:||:|.::.:..|.....:|||
  Rat   160 WVLSFTISCPL-LFGLNN-----TDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRK 218

  Fly   475 KARFAAEHPESELFRR-----LGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGE 534
            :.:.......|..||.     |.|..|     ..:.:::.:....||..|               
  Rat   219 RRKRVNTKRSSRAFRANLKTPLKGNCT-----HPEDMKLCTVIMKSNGSF--------------- 263

  Fly   535 MEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSG 599
                  |..|..::.|.|       |....|..:                               
  Rat   264 ------PVNRRRMDAARR-------AQELEMEML------------------------------- 284

  Fly   600 AGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTI 664
                  ||:||..                             ..|.|.:|||.|       ::|:
  Rat   285 ------SSTSPPE-----------------------------RTRYSPIPPSHH-------QLTL 307

  Fly   665 SQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGG 729
            ..|                           |..|..||                           
  Rat   308 PDP---------------------------SHHGLHSN--------------------------- 318

  Fly   730 NHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTL----NLRFLNNRSKRNSLSAN-----AV 785
                         |:.|    .:|.|....::..|.:    .::.:.|...|.||...     :.
  Rat   319 -------------PDSP----AKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQ 366

  Fly   786 ATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIF 850
            ..|:|||::|.:|...|::||.||||.:|:...| :|.:|..:.:...|||||:|.:||||||.|
  Rat   367 QKEKKATQMLAIVLGVFIICWLPFFITHILNIHC-DCNIPPVLYSAFTWLGYVNSAVNPIIYTTF 430

  Fly   851 NRTFRAAFIRLLKC 864
            |..||.||:::|.|
  Rat   431 NIEFRKAFMKILHC 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 68/176 (39%)
TM helix 2 321..343 CDD:410628 13/21 (62%)
TM helix 3 359..381 CDD:410628 11/21 (52%)
TM helix 4 404..420 CDD:410628 7/15 (47%)
TM helix 5 443..466 CDD:410628 8/22 (36%)
7tm_GPCRs <779..858 CDD:475119 35/83 (42%)
TM helix 6 792..814 CDD:410628 10/21 (48%)
TM helix 7 826..851 CDD:410628 12/24 (50%)
Drd2NP_036679.1 7tmA_D2_dopamine_R 35..438 CDD:320435 146/587 (25%)
TM helix 1 36..62 CDD:320435 9/25 (36%)
TM helix 2 69..92 CDD:320435 14/22 (64%)
TM helix 3 107..137 CDD:320435 15/29 (52%)
TM helix 4 152..170 CDD:320435 8/18 (44%)
TM helix 5 186..211 CDD:320435 10/24 (42%)
Interaction with PPP1R9B. /evidence=ECO:0000269|PubMed:10391935 211..374 46/339 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..329 20/190 (11%)
TM helix 6 367..397 CDD:320435 14/29 (48%)
TM helix 7 406..431 CDD:320435 12/24 (50%)

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