DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and Adra2b

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_612514.2 Gene:Adra2b / 24174 RGDID:2057 Length:453 Species:Rattus norvegicus


Alignment Length:630 Identity:158/630 - (25%)
Similarity:242/630 - (38%) Gaps:207/630 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   251 PNLTALNTTSTASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRK 315
            |.:......|..:||.:|:  |:|            ||.||.:|       ||.||.|||...|.
  Rat     4 PTMDHQEPYSVQATAAIAS--AIT------------FLILFTIF-------GNALVILAVLTSRS 47

  Fly   316 LQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFIS 380
            |:...|.||.|||.||:||:..::|.......||||.....||.:|:..|||.|:|||:|:|.||
  Rat    48 LRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAIS 112

  Fly   381 LGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPN---ICVINN 442
            |.||..:...|....:.|.|.....|..||::|.::|    :..|:.:.:..|||.   .|.:|.
  Rat   113 LDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVIS----LPPLIYKGDQRPEPRGLPQCELNQ 173

  Fly   443 RAFFVFGSLV-AFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGR------FTLRPQ 500
            .|:::..|.: :|:.|.|:|:..| |.|.::.|::.          .|.||.:      .:.:||
  Rat   174 EAWYILASSIGSFFAPCLIMILVY-LRIYVIAKRSH----------CRGLGAKRGSGEGESKKPQ 227

  Fly   501 HSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSM 565
            .....:...:......:...|:|:.|.:.....|.|||..|.     :|..|.|....:|..|  
  Rat   228 PVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPE-----DPEARALPPTWSALPR-- 285

  Fly   566 GTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIF----RHSSSSPASSCHSTSTSRSSSFW 626
               |.:....|||||         ||..........:.    :...:||||.|:           
  Rat   286 ---SGQGQKKGTSGA---------TAEEGDEEDEEEVEECEPQTLPASPASVCN----------- 327

  Fly   627 RKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAG 691
                                  ||             :.|||                       
  Rat   328 ----------------------PP-------------LQQPQ----------------------- 334

  Fly   692 GNGSSAGRTSNSSLGGTSLMKIATIQGPIL---NQSQAAGGNHMVQKVKPTALKPEEPQRNKVRP 753
                            ||.: :||::|.:|   |...|:|                         
  Rat   335 ----------------TSRV-LATLRGQVLLGKNVGVASG------------------------- 357

  Fly   754 FKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAA 818
                           ::...|::        ::.|::.|.||.:|...||:||.|||....:.|.
  Rat   358 ---------------QWWRRRTQ--------LSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAI 399

  Fly   819 CPE-CQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLL 862
            ||: |:||..:.....|:||.:|::||:|||:||:.||.||.|:|
  Rat   400 CPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRIL 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 64/178 (36%)
TM helix 2 321..343 CDD:410628 11/21 (52%)
TM helix 3 359..381 CDD:410628 11/21 (52%)
TM helix 4 404..420 CDD:410628 5/15 (33%)
TM helix 5 443..466 CDD:410628 6/23 (26%)
7tm_GPCRs <779..858 CDD:475119 31/79 (39%)
TM helix 6 792..814 CDD:410628 11/21 (52%)
TM helix 7 826..851 CDD:410628 9/24 (38%)
Adra2bNP_612514.2 7tmA_alpha2B_AR 12..440 CDD:320444 153/616 (25%)
TM helix 1 19..45 CDD:320444 15/46 (33%)
TM helix 2 52..78 CDD:320444 11/25 (44%)
TM helix 3 90..120 CDD:320444 16/29 (55%)
TM helix 4 132..155 CDD:320444 7/26 (27%)
TM helix 5 174..203 CDD:320444 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..331 31/182 (17%)
TM helix 6 367..397 CDD:320444 12/29 (41%)
TM helix 7 408..433 CDD:320444 9/24 (38%)

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