DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT2A and dop-3

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_001024908.2 Gene:dop-3 / 188499 WormBaseID:WBGene00020506 Length:607 Species:Caenorhabditis elegans


Alignment Length:665 Identity:163/665 - (24%)
Similarity:268/665 - (40%) Gaps:168/665 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   290 LFVVFFIFAGGL-----------GNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGA 343
            |.||.:..|.|:           ||:||.::|..:|.||.|||..:.|||::|.:|::.||..|.
 Worm    15 LMVVLWRVAAGVFLPLVPTMAVFGNVLVIMSVFRERSLQTVTNMLIVSLAVSDFMVAIGVMSFGV 79

  Fly   344 IPAFLGY-WPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLG-SRHRSTKRLTGIKI 406
            ...:..: |.||..:|::|...||...::|||::..|||.||:.|.:|:. :::.:......|.|
 Worm    80 YYEWNDFKWGLGSFFCHVYQALDVACSTASILNLLAISLDRYIAIGHPISYAQYGARGGRAMISI 144

  Fly   407 AIVWVMAMMVSSSITVLGLVN--EKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTI 469
            .|||.:::.|:..: :|| ||  |:|.:.|   |.:.|..|.:..|:.:|:||.:.|:..|.:..
 Worm   145 TIVWGVSVAVALPL-LLG-VNPMEENDLQE---CELANPYFNMISSIFSFFIPCIAMIILYTIIF 204

  Fly   470 PLLRKKARF----AAEHPE-----------SELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKF 519
            ..||::.|.    .|:..|           :::.|::|..|..|..      |:....|...:.|
 Worm   205 RRLRQRERARSLRQAQRSENDKISSALLGGAQIARQMGKHFKNRTD------QILLEISFQTSSF 263

  Fly   520 LSMGDGNRNFNTEGEM-----------------------EEGGAPSRRSGVEPAERPLMQQRTAS 561
            .:|.:.:.:.:|...|                       |.|..|:    :...|||    ....
 Worm   264 PTMSESSEDASTISPMINSFNNFLPKKTPYPSTSIPAIPECGSMPN----LTIIERP----EAEK 320

  Fly   562 SRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFR---------FSGAGIFRHSSSSPASSCHST 617
            .:.:..:..|:.|........|...|:.....||.         ..|:...:||.....::..:|
 Worm   321 EKEISIMDLRDTVEMLDDKYSSAILTSFQTSRSFGEELEEILPFIDGSNSVKHSREQLHTTRSNT 385

  Fly   618 STSRSSSFWRKHGGYPNLMDRLAIHLRLSLVP---------------PSSHPNRRASVRVTISQP 667
            ||:|             |:| :...||...||               |.||.|.      |..|.
 Worm   386 STTR-------------LLD-VKPELRSISVPSIQDEKKLSQKSNDLPFSHQNG------THKQK 430

  Fly   668 QLGYPTNVGGNGGRTVGATEVGAGGNG----SSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAG 728
            .|..|..:..:...|:..|      ||    .|..|.|:..    ||..:........:.|....
 Worm   431 LLPNPGILMKSKSTTLLKT------NGYMDTDSLNRNSHKK----SLADLLANDEFSFSDSMRVY 485

  Fly   729 GNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATK 793
            .|.:.:     :|.......||.||.:   :.|...|..:|                 .|.|||.
 Worm   486 KNRLFK-----SLSRATSGWNKPRPSR---HMVKKATKQMR-----------------REHKATV 525

  Fly   794 VLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCL---------WLGYVSSTINPIIYTI 849
            .|.:|...|:.||.|||:|::..:.|  ..:.|:  :.|:         ||||::|::||:|||:
 Worm   526 TLAVVLAVFLFCWLPFFVLHLSNSIC--LIIDEN--SACVGFLPLYLATWLGYLNSSLNPLIYTV 586

  Fly   850 FNRTFRAAFIRLLKC 864
            |::.||.||..:|.|
 Worm   587 FDQRFRNAFRNILSC 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 60/189 (32%)
TM helix 2 321..343 CDD:410628 8/21 (38%)
TM helix 3 359..381 CDD:410628 7/21 (33%)
TM helix 4 404..420 CDD:410628 6/15 (40%)
TM helix 5 443..466 CDD:410628 6/22 (27%)
7tm_GPCRs <779..858 CDD:475119 29/87 (33%)
TM helix 6 792..814 CDD:410628 10/21 (48%)
TM helix 7 826..851 CDD:410628 12/33 (36%)
dop-3NP_001024908.2 7tmA_D2-like_dopamine_R 22..>204 CDD:320181 60/186 (32%)
TM helix 1 23..49 CDD:320181 7/25 (28%)
TM helix 2 56..82 CDD:320181 10/25 (40%)
TM helix 3 95..125 CDD:320181 12/29 (41%)
TM helix 4 138..161 CDD:320181 6/23 (26%)
TM helix 5 177..204 CDD:320181 8/26 (31%)
7tm_GPCRs <515..595 CDD:475119 30/100 (30%)
TM helix 6 524..546 CDD:410628 10/21 (48%)
TM helix 7 563..588 CDD:410628 10/24 (42%)

Return to query results.
Submit another query.