Protein Alignment 5-HT2A and tyra-3

DIOPT Version :10

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_001024805.1
• Gene: tyra-3 / 187427
• WormBaseID: WBGene00006475
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 735
• Identity: 186/735 - (25%)
• Similarity: 278/735 - (37%)
• Gaps: 219/735 - (29%)

  Fly   191 EVGSAEESFSNDSLLQAF---QIELGAERDGLWSFLNLSELMEPDHGFLGIMNVTNTSLDMFLPN 252
            |:.||:..|.:......|   |..||.   .||:.::..|         |.::         ||:
 Worm     8 EILSAKSDFESIMAWSVFIYIQAALGG---SLWTSISTPE---------GSVS---------LPS 51

  Fly   253 LTALNTTSTAST-----ADMATEFAVT----KSFLDYSP-------HGYDFLFLFVVFFIFAGGL 301
            .|....|||..|     :..:..||.|    ....:|.|       |.. |:.||:|..|.....
 Worm    52 STTATITSTTVTPVWVASKNSIPFADTLGSNSPLSEYLPVKLCLGIHDV-FIALFLVMLILLTIF 115

  Fly   302 GNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGY-WPLGFTWCNIYVTCD 365
            |||||.|:|.:.::::..||..|.|||.|||||.|.||||..:.....: ||||...|.::.|.|
 Worm   116 GNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRWPLGRFLCRMWATSD 180

  Fly   366 VLACSSSILHMCFISLGRYMGIRNPLG-SRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEK 429
            ||.|::|||::|.|||.||..|.:||. .|.||.|...|: :..||.::.:|.|...|:
 Worm   181 VLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGL-LTAVWAISFVVCSPPWVI------ 238

  Fly   430 NIMPEPNICVINNR----------------AFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARF 478
               |..|:.:.||.                |:.::.:|.:||:|:|:|:..|.       |..|.
 Worm   239 ---PSWNLFIDNNNNTGSSEDFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYF-------KIFRV 293

  Fly   479 AAEHPESELFR------RLGGRFTLRPQHSQQQLQMFSSFSGSNNKF-LSMGDGNRNFNTEGEME 536
            |:|  ...|.|      ||..|.|...|.:|:.....:|...|..:. ::...|..|::..
 Worm   294 ASE--REALMRQSVGTCRLSNRLTKTQQKNQRNNLRTASAPHSRTRVQVNHNCGRVNYSVR---- 352

  Fly   537 EGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGA- 600
                     .||.|.|.....:.:..|...|....:..||.|..||    ||.....|...:..
 Worm   353 ---------PVEYANRVENSLKPSHERFDSTDCEDSPPNGDSLEAG----TTCNISMSLVTNSPP 404

  Fly   601 -GIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTI 664
             |:.:.:.:|....|||.:                           .:|..:..|.|:
 Worm   405 NGLQKEAKNSMERECHSLA---------------------------DIVNSADTPVRK------- 435

  Fly   665 SQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIA----TIQGPILNQSQ 725
                                .||||...:.|...|..|:.|...:|::.|    .|.||
 Worm   436 --------------------NTEVGVAPSLSKRARQCNARLQPNNLLQKAHEHYQINGP------ 474

  Fly   726 AAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQK 790
                                                           .::.|.|........|:|
 Worm   475 -----------------------------------------------GKAVRGSKEKMVYMRERK 492

  Fly   791 ATKVLGLVFFTFVLCWSPFFILNI--IFAACPECQVPEHVVNT--CLWLGYVSSTINPIIYTIFN 851
            |.|.:|:|...|::||.||||:.:  :|.:.|..:.|.:.:.:  .|||||.:|.:||||||::|
 Worm   493 ALKTIGIVVLGFIICWMPFFIMYLVEVFISDPVAESPIYRITSEFFLWLGYSNSVLNPIIYTMYN 557

  Fly   852 RTFRAAFIRLLKCNCKRSGR 871
            ..||..|..||...|.:..|
 Worm   558 GDFRRCFRDLLSFGCVQHHR 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	67/192 (35%)
		TM helix 2	321..343	CDD:410628	15/21 (71%)
		TM helix 3	359..381	CDD:410628	10/21 (48%)
		TM helix 4	404..420	CDD:410628	4/15 (27%)
		TM helix 5	443..466	CDD:410628	7/38 (18%)
		7tm_GPCRs	<779..858	CDD:475119	32/82 (39%)
		TM helix 6	792..814	CDD:410628	10/21 (48%)
		TM helix 7	826..851	CDD:410628	12/26 (46%)
tyra-3	NP_001024805.1	7tmA_tyramine_R-like	101..>300	CDD:320189	76/217 (35%)
		TM helix 1	101..127	CDD:320189	12/25 (48%)
		TM helix 2	134..160	CDD:320189	16/25 (64%)
		TM helix 3	173..203	CDD:320189	15/29 (52%)
		TM helix 4	215..238	CDD:320189	6/23 (26%)
		TM helix 5	264..289	CDD:320189	8/31 (26%)
		7tm_GPCRs	<486..564	CDD:475119	31/77 (40%)
		TM helix 6	494..516	CDD:320189	10/21 (48%)
		TM helix 7	532..557	CDD:320189	12/24 (50%)