DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and octr-1

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_001024569.1 Gene:octr-1 / 184469 WormBaseID:WBGene00006411 Length:408 Species:Caenorhabditis elegans


Alignment Length:576 Identity:118/576 - (20%)
Similarity:200/576 - (34%) Gaps:214/576 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 LFLFVVFFIFAGGLGNILVCLAVALDRKLQ-NVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYW 351
            :.|.::|       ||:||.:.|..||||: ...|:.:.|||:||:||.|.|||:......:|.|
 Worm    31 VMLLIIF-------GNLLVVVTVYRDRKLRMQRQNWLIVSLAVADMLVGLLVMPLTLTYEIVGEW 88

  Fly   352 PLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMV 416
            .:|...|.|::..|||..::||||:|.|||.||..:.:||......|.....|.|.:.|::::::
 Worm    89 TMGNILCEIWLALDVLFVTASILHICAISLDRYFSVTSPLTYPATRTPLRMFIYIGVSWIVSLLI 153

  Fly   417 SSSITVLGLVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAE 481
            ... .:.|...|:   .|....|..:..:.::.||.:||||:::::..||..             
 Worm   154 CLP-PIFGWRPER---AEGECSVSTDLGYVLYSSLGSFYIPVVILIIVYAKI------------- 201

  Fly   482 HPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSG 546
                         :::..:||:|:|:.......:.|........|..:|.|.|:||...|     
 Worm   202 -------------YSITIRHSRQRLKETERRDHTLNMLTIRSSTNERYNMEYELEENSDP----- 248

  Fly   547 VEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPA 611
            :|..:..::..|                                                     
 Worm   249 IEDEKEKVVTNR----------------------------------------------------- 260

  Fly   612 SSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVG 676
                                  ::::::...||                :::...|:.|...:: 
 Worm   261 ----------------------DMINKVCWQLR----------------KISEELPRQGVKVSI- 286

  Fly   677 GNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTAL 741
                                                             |...||..........
 Worm   287 -------------------------------------------------ALDTNHNSPPASDLTR 302

  Fly   742 KPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCW 806
            |.||.                      :|...|.::      ..|.|::||.:||::...|:|.|
 Worm   303 KLEEK----------------------KFCEKRKRK------LKAKERQATLLLGIILSAFILSW 339

  Fly   807 SPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLL 862
            .|||::.:|.|...|  .|..|.....||||.:|.|||:|||:|||.|:....:.|
 Worm   340 LPFFLIYVIGAFGHE--APPLVFKFFFWLGYCNSGINPVIYTVFNREFKRGLCKQL 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 57/175 (33%)
TM helix 2 321..343 CDD:410628 12/21 (57%)
TM helix 3 359..381 CDD:410628 10/21 (48%)
TM helix 4 404..420 CDD:410628 3/15 (20%)
TM helix 5 443..466 CDD:410628 6/22 (27%)
7tm_GPCRs <779..858 CDD:475119 32/78 (41%)
TM helix 6 792..814 CDD:410628 9/21 (43%)
TM helix 7 826..851 CDD:410628 12/24 (50%)
octr-1NP_001024569.1 7tmA_alpha2_AR 22..389 CDD:320187 117/570 (21%)
TM helix 1 23..49 CDD:320187 7/24 (29%)
TM helix 2 57..83 CDD:320187 12/25 (48%)
TM helix 3 95..125 CDD:320187 15/29 (52%)
TM helix 4 137..160 CDD:320187 3/23 (13%)
TM helix 5 175..204 CDD:320187 8/54 (15%)
TM helix 6 319..349 CDD:320187 12/29 (41%)
TM helix 7 357..382 CDD:320187 12/24 (50%)

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