Protein Alignment 5-HT2A and ser-2

DIOPT Version :9

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_001024339.1
• Gene: ser-2 / 182110
• WormBaseID: WBGene00004777
• Length: 455
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 147/583 - (25%)
• Similarity: 221/583 - (37%)
• Gaps: 207/583 - (35%)

  Fly   301 LGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFL--GYWPLGFTWCNIYVT 363
            :||.||.:||...|.|:.|.||||.|||.:||.|::||||:..: .||  |.|.||.|.|..:.|
 Worm    73 VGNTLVVVAVFSYRPLKKVQNYFLVSLAASDLAVAIFVMPLHVV-TFLAGGKWLLGVTVCQFFTT 136

  Fly   364 CDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNE 428
            .|:|.|:||||::|.|:|.||..|.||:....:.|.:...|.|.|||:::|::|.. .::|..|.
 Worm   137 ADILLCTSSILNLCAIALDRYWAIHNPINYAQKRTTKFVCIVIVIVWILSMLISVP-PIIGWNNW 200

  Fly   429 KNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGG 493
            :..|.|.:..:...:||.||.:..:|::|:|:||..|.......|::.|
 Worm   201 QENMMEDSCGLSTEKAFVVFSAAGSFFLPLLVMVVVYVKIFISARQRIR---------------- 249

  Fly   494 RFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQR 558
              |.|.:.:..::|                      |.||:.:......:|:.||.|       |
 Worm   250 --TNRGRSALMRIQ----------------------NAEGDDDYRKMSIKRASVESA-------R 283

  Fly   559 TASSRSMGTVSFRNVVNGTSGAAGSGRRTTGT--AHSSFRFSGAGIFRHSSSSPASSCHSTSTSR 621
            |:|          .|...|......|:.|..|  |||:   .|..:.:..::
 Worm   284 TSS----------RVGEKTPLVIADGQTTVTTLAAHST---DGGSLPKDETT------------- 322

  Fly   622 SSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGAT 686
                  ||..|.|
 Worm   323 ------KHMKYHN---------------------------------------------------- 329

  Fly   687 EVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKV 751
                  |||.                                      |||...:|.:|...|
 Worm   330 ------NGSC--------------------------------------KVKVKDVKEDEGNPN-- 348

  Fly   752 RPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIF 816
                        ||..||      ||..:|   ||.|::|.|.:.::.|.|..||.|||:..:|.
 Worm   349 ------------PTAVLR------KREKIS---VAKEKRAAKTIAVIIFVFSFCWLPFFVAYVIR 392

  Fly   817 AACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCKRSGRPLRYRSVT 879
            ..|..|::...|.....||||::|::||.:|.|.|..||.||.::|   |.::....|.|.::
 Worm   393 PFCETCKLHAKVEQAFTWLGYINSSLNPFLYGILNLEFRRAFKKIL---CPKAVLEQRRRRMS 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_4	299..>428	CDD:304433	56/128 (44%)
		7tm_1	302..>477	CDD:278431	70/176 (40%)
ser-2	NP_001024339.1	7tm_1	74..423	CDD:278431	136/548 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910