DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and ser-1

DIOPT Version :9

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_001024728.1 Gene:ser-1 / 181716 WormBaseID:WBGene00004776 Length:683 Species:Caenorhabditis elegans


Alignment Length:740 Identity:209/740 - (28%)
Similarity:288/740 - (38%) Gaps:264/740 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 FLPNLTALNTT------STASTADMATEFAVTKSFLDYSPHGYDF----LFLFVVFFIFAGGLGN 303
            ::|...:..||      ||.|...:..:...|...       |.|    |||..|..:. |.:||
 Worm    17 YVPANESFATTALTPHFSTTSVWSIRVQLIPTMGI-------YHFNGVALFLLPVLCLI-GLIGN 73

  Fly   304 ILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMG-AIPAFLGYWPLGFTWCNIYVTCDVL 367
            .|||:|:|.||:|.|||||||||||:|||||...|||:. .:....|.|....:.|.:||..||.
 Worm    74 FLVCVAIATDRRLHNVTNYFLFSLALADLLVCCIVMPLSIVVEVRHGVWTWSVSMCLLYVYSDVF 138

  Fly   368 ACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIM 432
            .||:||:||..|||.||:||..||.:|:|| |.|..||||||||:.::||..|.||.:.:..||:
 Worm   139 LCSASIVHMSVISLDRYLGISQPLRTRNRS-KTLIFIKIAIVWVVTLLVSCPIAVLAMHDTANIL 202

  Fly   433 PEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTL 497
             ..|.|:|.:|.:.::||.:.|.||:.:|..|||.|..||.|:|        |.|.::.|.:|. 
 Worm   203 -RNNQCMIFSRYYIIYGSTMTFLIPLCIMGVTYAKTTQLLNKQA--------SILSQKAGDKFN- 257

  Fly   498 RPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASS 562
                                     |:|.|                              ||...
 Worm   258 -------------------------GNGLR------------------------------RTMPH 267

  Fly   563 RSMGTV-SFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFW 626
            |.:|.. ::...||||..                  :|..|..|                     
 Worm   268 RKLGYARTYSATVNGTIA------------------NGKAIGAH--------------------- 293

  Fly   627 RKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAG 691
                                                                 |||:  :.:...
 Worm   294 -----------------------------------------------------GRTM--SSISNI 303

  Fly   692 GNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKF 756
            .||.:|.|.      |||...|.|            .|:..:||..                   
 Worm   304 ANGETADRL------GTSRPSINT------------NGHKQLQKAS------------------- 331

  Fly   757 AFNRVATPTLNL--RFLNNRSKRNSL--SANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFA 817
            ..|:..:.|.||  .|.|...:|:||  :...:|.|.|||:||.:||..|.:||:|||.:|.:..
 Worm   332 TINKWKSRTSNLVTNFANKVGRRSSLQTATQDLANEHKATRVLAVVFACFFICWTPFFFINFLIG 396

  Fly   818 ACPE-CQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNC---KRSGRPLRYRSV 878
            ...| .|:|:.|.:..||||||||||||||||:||:.||.||:|:|:|.|   .|....:..|:.
 Worm   397 FGGENVQIPDWVASIFLWLGYVSSTINPIIYTVFNKRFRQAFVRILRCQCFHPLRDSHQMYSRNF 461

  Fly   879 T-------------------------EGRGALSLCAP---------SALPLA-----ISFQGAPL 904
            |                         |.|.|.|...|         |..|:|     ::.:...:
 Worm   462 TTTIVPDTYTCSRSNQERTTSVITRDETRSARSSERPEPSRARSEISEEPVARTNGKLTSEKKKI 526

  Fly   905 MTPSTANATPMSEFRASCRTVTDDE 929
            ..||....:...:.||:....|.||
 Worm   527 SLPSFPRVSSSRDSRATTEASTTDE 551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_4 299..>428 CDD:304433 70/129 (54%)
7tm_1 302..>477 CDD:278431 88/175 (50%)
ser-1NP_001024728.1 7tmA_5-HT2 56..438 CDD:320180 176/579 (30%)
TM helix 1 57..83 CDD:320180 12/26 (46%)
TM helix 2 90..116 CDD:320180 17/25 (68%)
TM helix 3 129..159 CDD:320180 17/29 (59%)
TM helix 4 170..193 CDD:320180 12/22 (55%)
TM helix 5 211..240 CDD:320180 11/28 (39%)
TM helix 6 365..395 CDD:320180 16/29 (55%)
TM helix 7 406..431 CDD:320180 17/24 (71%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001488
OrthoInspector 1 1.000 - - oto18049
orthoMCL 1 0.900 - - OOG6_109927
Panther 1 1.100 - - LDO PTHR24247
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4934
SonicParanoid 1 1.000 - - X759
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.940

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