Protein Alignment 5-HT2A and DRD4

DIOPT Version :10

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_000788.2
• Gene: DRD4 / 1815
• HGNCID: 3025
• Length: 419
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 56/327 - (17%)
• Similarity: 102/327 - (31%)
• Gaps: 122/327 - (37%)

  Fly   184 PGSLAAWFRQKYPQLTVGSVASSAPVNLKLDFYEYAMVVEDD----------------------- 225
            |.::.|..::||...:    ||...:..|..|.:...:.|||
Human    32 PLTVEARIKEKYSTFS----ASGENIERKRFFRKSVEMTEDDKVAESSRRDERKAATNISRVDKV 92

  Fly   226 ----LR----ITDPKCAQAT----KDAF-----------VQMQKLALTAEGRNSLNNHFNLQPPF 267
                ||    :...:|::||    ||.|           .:|:.:|.:..||
Human    93 PTNVLRGGQEVKYEQCSKATSESSKDCFKEKTEKEMEEEAEMKAVATSPSGR------------- 144

  Fly   268 DANTTKLDINNFFGNIFNTYQGMTQYT-------------------------------------- 294
               ..|.||....|.....|:|:...|
Human   145 ---FLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIV 206

  Fly   295 --YDGQSNSTHSDKTVRKMCDIMTNAT-----ETDVVMRVENLFLWFNQMEPASANLTVMPNSYW 352
              ||...::....|.:..:.::||:.|     :...||:.:.|..|..|:   ...|..:.....
Human   207 RFYDSWESTLKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQI---LKGLQFLHTRTP 268

  Fly   353 DVISQ-VGSGDLNVLGPDGAAARGWMWLCCNEIGFLQTTNQGNNVFGTGVPLNLFIDMCTDMFGD 416
            .:|.: :...::.:.||.|:...|.:.|..     |..|:...:|.||  |..:..:|..:.:.:
Human   269 PIIHRDLKCDNIFITGPTGSVKIGDLGLAT-----LMRTSFAKSVIGT--PEFMAPEMYEEHYDE 326

  Fly   417 SM 418
            |:
Human   327 SV 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	24/127 (19%)
		TM helix 2	321..343	CDD:410628	5/21 (24%)
		TM helix 3	359..381	CDD:410628	5/21 (24%)
		TM helix 4	404..420	CDD:410628	2/15 (13%)
		TM helix 5	443..466	CDD:410628
		7tm_GPCRs	<779..858	CDD:475119
		TM helix 6	792..814	CDD:410628
		TM helix 7	826..851	CDD:410628
DRD4	NP_000788.2	7tmA_D4_dopamine_R	38..411	CDD:320434	54/321 (17%)
		TM helix 1	38..62	CDD:320434	6/27 (22%)
		TM helix 2	69..95	CDD:320434	1/25 (4%)
		TM helix 3	108..138	CDD:320434	7/29 (24%)
		TM helix 4	150..173	CDD:320434	5/22 (23%)
		TM helix 5	189..218	CDD:320434	2/28 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..264		8/36 (22%)
		4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P	249..312		15/72 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..336		2/12 (17%)
		TM helix 6	339..369	CDD:320434
		TM helix 7	379..404	CDD:320434