DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and ser-4

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_497452.1 Gene:ser-4 / 175322 WormBaseID:WBGene00004779 Length:445 Species:Caenorhabditis elegans


Alignment Length:632 Identity:146/632 - (23%)
Similarity:246/632 - (38%) Gaps:215/632 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 TALNTTSTASTADMATEFAVTKS--FLDYSP-HGYDF------------LFLFVVFFIFAGGLGN 303
            |.||.|::.|:.......||.:.  .:|..| |...|            |...::..|.:..:||
 Worm     5 TLLNLTASPSSQPATLLSAVARGTHLVDQFPAHAEIFSDIERPLVQTVILASVLLVLILSCFIGN 69

  Fly   304 ILVCLAVALDRKLQNVTNYFL-FSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVL 367
            :.|.||:.::|.|:....|:| ||||:|||||.:.|.|:||.....|.|.||...|:.:::.|||
 Worm    70 LFVILAIIMERDLRGRPQYYLIFSLAVADLLVGMIVTPLGAWFTVTGTWNLGVVVCDFWISVDVL 134

  Fly   368 ACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNE--KN 430
            .|::||||:..|:|.||..|.:....::|:.||:| :.:|::|..::::|.: ...|..:|  .:
 Worm   135 VCTASILHLVAIALDRYWSITDICYVQNRTPKRIT-LMLAVIWFTSLLISLA-PFAGWKDEGFSD 197

  Fly   431 IMPEPNICVINNR-AFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGR 494
            .:.:.::|:|:.: ::.||.:..|||||::.::..|...:...:|  ||..|.            
 Worm   198 RVLKSHVCLISQQISYQVFSTATAFYIPLIAIICVYWKIMRAAKK--RFKRER------------ 248

  Fly   495 FTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRT 559
                                                           .||:.:.|....:.::: 
 Worm   249 -----------------------------------------------DRRTVIRPPPDAIDEKK- 265

  Fly   560 ASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSS 624
                                                    |.:.:.|...|              
 Worm   266 ----------------------------------------AMMPKKSKKCP-------------- 276

  Fly   625 FWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVG 689
                                   :||:          |.||..|..     ||.||:|.......
 Worm   277 -----------------------LPPA----------VVISDIQAN-----GGTGGKTNSIKNPP 303

  Fly   690 AGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPF 754
            .....||:                |:.:...:.|:..|.|:...|:.|    ..||..|:|    
 Worm   304 RHNESSSS----------------ASEEERTMTQTNHAPGDVTTQETK----IDEENGRSK---- 344

  Fly   755 KFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAAC 819
                     |.:..|      :|.:..:|.:..|:||.:.|.::..|||.||:|||:::|....|
 Worm   345 ---------PGIVKR------RRRTKESNEMKRERKAWRTLAIITGTFVACWTPFFLVSIYRPIC 394

  Fly   820 PECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNC 866
             .||:...:....|||||::|.:||||||:|::.|||||.|::|..|
 Worm   395 -GCQISPVLEQVTLWLGYLNSALNPIIYTVFSQDFRAAFKRIIKRMC 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 59/178 (33%)
TM helix 2 321..343 CDD:410628 13/22 (59%)
TM helix 3 359..381 CDD:410628 9/21 (43%)
TM helix 4 404..420 CDD:410628 3/15 (20%)
TM helix 5 443..466 CDD:410628 7/23 (30%)
7tm_GPCRs <779..858 CDD:475119 33/78 (42%)
TM helix 6 792..814 CDD:410628 9/21 (43%)
TM helix 7 826..851 CDD:410628 12/24 (50%)
ser-4NP_497452.1 7tmA_5-HT1A_invertebrates 52..432 CDD:320454 130/575 (23%)
TM helix 1 53..79 CDD:320454 7/25 (28%)
TM helix 2 87..113 CDD:320454 15/25 (60%)
TM helix 3 125..155 CDD:320454 13/29 (45%)
TM helix 4 166..188 CDD:320454 6/23 (26%)
TM helix 5 210..239 CDD:320454 8/28 (29%)
TM helix 6 361..391 CDD:320454 13/29 (45%)
TM helix 7 400..425 CDD:320454 12/24 (50%)

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