Protein Alignment 5-HT2A and ADRB3

DIOPT Version :10

• Sequence 1: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Sequence 2: NP_000016.1
• Gene: ADRB3 / 155
• HGNCID: 288
• Length: 408
• Species: Homo sapiens
• Alignment Length: 674
• Identity: 146/674 - (21%)
• Similarity: 213/674 - (31%)
• Gaps: 300/674 - (44%)

  Fly   243 NTSLDMF--LPNLTALNTTSTASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNIL 305
            |:||..:  ||.| |.||.:|:....:..|.|:..:.|              ...:.|...||:|
Human     8 NSSLAPWPDLPTL-APNTANTSGLPGVPWEAALAGALL--------------ALAVLATVGGNLL 57

  Fly   306 VCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACS 370
            |.:|:|...:||.:||.|:.|||.|||::.|.|:|..|..|..|:||||.|.|.::.:.|||..:
Human    58 VIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVT 122

  Fly   371 SSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNE------- 428
            :||..:|.:::.||:.:.|||......|||.....:.:|||    ||::::...::::
Human   123 ASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWV----VSAAVSFAPIMSQWWRVGAD 183

  Fly   429 ---KNIMPEPNICVI-NNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFR 489
               :.....|..|.. :|..:.:..|.|:||:|:|:|:..||....:..::.|         |.|
Human   184 AEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLR---------LLR 239

  Fly   490 RLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPL 554
            ...|||                                                    .|.|.|
Human   240 GELGRF----------------------------------------------------PPEESP- 251

  Fly   555 MQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTST 619
                .|.|||:                                         :.:|..:|
Human   252 ----PAPSRSL-----------------------------------------APAPVGTC----- 266

  Fly   620 SRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVG 684
                                        .||...|
Human   267 ----------------------------APPEGVP------------------------------ 273

  Fly   685 ATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRN 749
                       :.||                                     :|..|.|
Human   274 -----------ACGR-------------------------------------RPARLLP------ 284

  Fly   750 KVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNI 814
                              ||                  |.:|...|||:..||.|||.|||:.|:
Human   285 ------------------LR------------------EHRALCTLGLIMGTFTLCWLPFFLANV 313

  Fly   815 IFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCKRSGRPLRYRSVT 879
            :.|......||........||||.:|..||:|| ..:..||:||.||| |.|   ||.|......
Human   314 LRALGGPSLVPGPAFLALNWLGYANSAFNPLIY-CRSPDFRSAFRRLL-CRC---GRRLPPEPCA 373

  Fly   880 EGRGALSLCAPSALPLAISFQGAP 903
            ..|.||   .||.:|.|.|....|
Human   374 AARPAL---FPSGVPAARSSPAQP 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	61/185 (33%)
		TM helix 2	321..343	CDD:410628	11/21 (52%)
		TM helix 3	359..381	CDD:410628	6/21 (29%)
		TM helix 4	404..420	CDD:410628	5/15 (33%)
		TM helix 5	443..466	CDD:410628	7/22 (32%)
		7tm_GPCRs	<779..858	CDD:475119	28/78 (36%)
		TM helix 6	792..814	CDD:410628	11/21 (52%)
		TM helix 7	826..851	CDD:410628	9/24 (38%)
ADRB3	NP_000016.1	7tm_GPCRs	51..356	CDD:475119	113/569 (20%)
		TM helix 2	73..95	CDD:320625	11/21 (52%)
		TM helix 3	111..133	CDD:320625	6/21 (29%)
		TM helix 4	156..172	CDD:320625	5/19 (26%)
		TM helix 5	202..225	CDD:320625	7/22 (32%)
		TM helix 6	291..313	CDD:320625	11/21 (52%)
		TM helix 7	325..350	CDD:320625	9/25 (36%)