DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT2A and ADRA2C

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_000674.2 Gene:ADRA2C / 152 HGNCID:283 Length:462 Species:Homo sapiens


Alignment Length:581 Identity:138/581 - (23%)
Similarity:209/581 - (35%) Gaps:193/581 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   287 FLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYW 351
            ||.:|.|       :||:||.:||...|.|:...|.||.|||.||:||:..|||.......:.||
Human    60 FLIVFTV-------VGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYW 117

  Fly   352 PLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMV 416
            ..|..||.:|:..|||.|:|||:|:|.|||.||..:...:....:.|.|.....|..||:::.::
Human   118 YFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVI 182

  Fly   417 SSSITVLGLVNEKNIMPEPNICVINNRAFFVFGSLV-AFYIPMLMMVTTYALTIPLLRKKARFAA 480
            |.. .::.|..:.:....|. |.:|:..:::..|.: :|:.|.|:|...||....:.:.:.|   
Human   183 SFP-PLVSLYRQPDGAAYPQ-CGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTR--- 242

  Fly   481 EHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRS 545
                                                                 .:.|..||....
Human   243 -----------------------------------------------------TLSEKRAPVGPD 254

  Fly   546 GVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSP 610
            |..|...                      ||...|||:|..                 .|.:..|
Human   255 GASPTTE----------------------NGLGAAAGAGEN-----------------GHCAPPP 280

  Fly   611 ASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNV 675
            |    ......||:                         .:....||.::|              
Human   281 A----DVEPDESSA-------------------------AAERRRRRGALR-------------- 302

  Fly   676 GGNGGRTVGATEVGAGG-NGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPT 739
              .|||.....|.|||| :|..||..:..|...|:            ::|...||.         
Human   303 --RGGRRRAGAEGGAGGADGQGAGPGAAESGALTA------------SRSPGPGGR--------- 344

  Fly   740 ALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAV--ATEQKATKVLGLVFFTF 802
                              .:|.::.::.......|..|:|:....|  |.|::.|.||.:|...|
Human   345 ------------------LSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVF 391

  Fly   803 VLCWSPFFILNIIFAACPE-CQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLL 862
            ||||.|||....::..|.| ||||..:.....|:||.:|::||:|||:||:.||.:|..:|
Human   392 VLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHIL 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 58/175 (33%)
TM helix 2 321..343 CDD:410628 13/21 (62%)
TM helix 3 359..381 CDD:410628 11/21 (52%)
TM helix 4 404..420 CDD:410628 4/15 (27%)
TM helix 5 443..466 CDD:410628 5/23 (22%)
7tm_GPCRs <779..858 CDD:475119 35/81 (43%)
TM helix 6 792..814 CDD:410628 12/21 (57%)
TM helix 7 826..851 CDD:410628 9/24 (38%)
ADRA2CNP_000674.2 7tmA_alpha2C_AR 60..448 CDD:320446 136/575 (24%)
TM helix 2 86..112 CDD:320446 13/25 (52%)
TM helix 3 124..154 CDD:320446 16/29 (55%)
TM helix 4 166..189 CDD:320446 5/23 (22%)
TM helix 5 207..236 CDD:320446 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..347 35/223 (16%)
TM helix 6 375..405 CDD:320446 14/29 (48%)
TM helix 7 416..441 CDD:320446 9/24 (38%)

Return to query results.
Submit another query.