DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and ADRA2B

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_000673.2 Gene:ADRA2B / 151 HGNCID:282 Length:450 Species:Homo sapiens


Alignment Length:637 Identity:157/637 - (24%)
Similarity:230/637 - (36%) Gaps:237/637 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   260 STASTADMATEFAVTKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFL 324
            |..:||.:|.  |:|            ||.||.:|       ||.||.|||...|.|:...|.||
Human     8 SVQATAAIAA--AIT------------FLILFTIF-------GNALVILAVLTSRSLRAPQNLFL 51

  Fly   325 FSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRN 389
            .|||.||:||:..::|.......||||....|||.:|:..|||.|:|||:|:|.|||.||..:..
Human    52 VSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSR 116

  Fly   390 PLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPN---ICVINNRAFFVFGSL 451
            .|....:.|.|.....|..||::|.::|    :..|:.:.:..|:|.   .|.:|..|:::..|.
Human   117 ALEYNSKRTPRRIKCIILTVWLIAAVIS----LPPLIYKGDQGPQPRGRPQCKLNQEAWYILASS 177

  Fly   452 V-AFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQH----SQQQLQMFSS 511
            : :|:.|.|:|:..| |.|.|:.|::.  ...|.::.....|.....||.|    :..:|...:|
Human   178 IGSFFAPCLIMILVY-LRIYLIAKRSN--RRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239

  Fly   512 FSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNG 576
            .:       |..:.|.:..:.||.|||..|.     :...|.|.....|...|            
Human   240 VA-------SAREVNGHSKSTGEKEEGETPE-----DTGTRALPPSWAALPNS------------ 280

  Fly   577 TSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSS-----------------------SPASSCHSTS 618
                 |.|::             .|:...|..                       ||||:|.   
Human   281 -----GQGQK-------------EGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACS--- 324

  Fly   619 TSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTV 683
                                          ||             :.|||          |.|. 
Human   325 ------------------------------PP-------------LQQPQ----------GSRV- 335

  Fly   684 GATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPIL--NQSQAAGGNHMVQKVKPTALKPEEP 746
                                         :||::|.:|  ....|.||....::.:.|       
Human   336 -----------------------------LATLRGQVLLGRGVGAIGGQWWRRRAQLT------- 364

  Fly   747 QRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFI 811
                                                    .|::.|.||.:|...|||||.|||.
Human   365 ----------------------------------------REKRFTFVLAVVIGVFVLCWFPFFF 389

  Fly   812 LNIIFAACPE-CQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLL 862
            ...:.|.||: |:||..:.....|:||.:|::||:||||||:.||.||.|:|
Human   390 SYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 65/178 (37%)
TM helix 2 321..343 CDD:410628 11/21 (52%)
TM helix 3 359..381 CDD:410628 11/21 (52%)
TM helix 4 404..420 CDD:410628 5/15 (33%)
TM helix 5 443..466 CDD:410628 6/23 (26%)
7tm_GPCRs <779..858 CDD:475119 33/79 (42%)
TM helix 6 792..814 CDD:410628 12/21 (57%)
TM helix 7 826..851 CDD:410628 10/24 (42%)
ADRA2BNP_000673.2 7tmA_alpha2B_AR 7..437 CDD:320444 153/631 (24%)
TM helix 1 14..40 CDD:320444 15/46 (33%)
TM helix 2 47..73 CDD:320444 11/25 (44%)
TM helix 3 85..115 CDD:320444 16/29 (55%)
TM helix 4 127..150 CDD:320444 7/26 (27%)
TM helix 5 169..198 CDD:320444 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..229 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..329 23/175 (13%)
TM helix 6 364..394 CDD:320444 14/76 (18%)
TM helix 7 405..430 CDD:320444 10/24 (42%)

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