DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and Octbeta2R

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:XP_003436280.1 Gene:Octbeta2R / 1273081 VectorBaseID:AGAMI1_002356 Length:526 Species:Anopheles gambiae


Alignment Length:604 Identity:136/604 - (22%)
Similarity:201/604 - (33%) Gaps:266/604 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   292 VVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFT 356
            ::|.|.|...||:||.::|...|||:.:||||:.|||:||::|::..|.........|.|..|..
Mosquito   139 MMFIIVAAIFGNLLVIISVKRHRKLRVITNYFVVSLAMADIMVAMMAMTFNFSVQITGSWKFGSF 203

  Fly   357 WCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSIT 421
            .|:::.:.||...::||||:|.||:.||..|..||......|||:..|.:...|:...::|....
Mosquito   204 MCDVWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVAIMLLNTWISPALLSFVPI 268

  Fly   422 VLG-LVNEKN---IMPEPNICV-INNRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAE 481
            ..| ...||:   ::..|:.|: |.|:.:.|..|.::|:||..:||.||                
Mosquito   269 FAGWYTTEKHKQEVLDNPDSCLFIVNKPYAVISSSISFFIPCTIMVFTY---------------- 317

  Fly   482 HPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSG 546
               .::||                                  :.||                   
Mosquito   318 ---FQIFR----------------------------------EANR------------------- 326

  Fly   547 VEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPA 611
                     |::..:.|.                        |||                    
Mosquito   327 ---------QEKQLALRQ------------------------GTA-------------------- 338

  Fly   612 SSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVG 676
                                                                    .|.:..|.|
Mosquito   339 --------------------------------------------------------MLMHQHNTG 347

  Fly   677 GNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTAL 741
            |           |.||.||..| |:..:|.|:...|..|:              |.|...:    
Mosquito   348 G-----------GVGGGGSGGG-TNGEALSGSGSSKTLTL--------------HEVDAEQ---- 382

  Fly   742 KPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCW 806
                                 |||.:...:  :.||          |.||.:.||::..||:|||
Mosquito   383 ---------------------TPTKDRHLI--KMKR----------EHKAARTLGIIMGTFILCW 414

  Fly   807 SPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKC------- 864
            .|||:..||.:.|..|..|:.||....|:||.:||:||:||..|||.||.||...|.|       
Mosquito   415 LPFFLWYIITSLCDRCPNPDIVVALVFWIGYFNSTLNPLIYAYFNRDFREAFRNTLDCMFCAWWR 479

  Fly   865 --------NCKRSGRPLRY 875
                    |.:|:.  |||
Mosquito   480 RETSPLDINVRRAS--LRY 496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 60/179 (34%)
TM helix 2 321..343 CDD:410628 10/21 (48%)
TM helix 3 359..381 CDD:410628 8/21 (38%)
TM helix 4 404..420 CDD:410628 3/15 (20%)
TM helix 5 443..466 CDD:410628 8/22 (36%)
7tm_GPCRs <779..858 CDD:475119 34/78 (44%)
TM helix 6 792..814 CDD:410628 10/21 (48%)
TM helix 7 826..851 CDD:410628 11/24 (46%)
Octbeta2RXP_003436280.1 7tmA_DmOct-betaAR-like 134..466 CDD:320194 127/570 (22%)
TM helix 1 134..160 CDD:320194 8/20 (40%)
TM helix 2 167..193 CDD:320194 11/25 (44%)
TM helix 3 205..235 CDD:320194 12/29 (41%)
TM helix 4 247..270 CDD:320194 4/22 (18%)
TM helix 5 294..323 CDD:320194 12/81 (15%)
TM helix 6 394..424 CDD:320194 16/39 (41%)
TM helix 7 434..459 CDD:320194 11/24 (46%)

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