DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and Adra2a

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:NP_031443.4 Gene:Adra2a / 11551 MGIID:87934 Length:465 Species:Mus musculus


Alignment Length:656 Identity:166/656 - (25%)
Similarity:230/656 - (35%) Gaps:225/656 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 SFLNLSELMEPDHGFLGIMNVTNTSLDMFLPNLTALNTTSTASTADMATEFA--VTKSFLDYSPH 283
            ||..:..| :||.|        |:|          .|.|........||.::  ||.:.:..:  
Mouse    12 SFAPMGSL-QPDAG--------NSS----------WNGTEAPGGGTRATPYSLQVTLTLVCLA-- 55

  Fly   284 GYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFL 348
              ..|.||.||       ||:||.:||...|.|:...|.||.|||.||:||:..|:|.......:
Mouse    56 --GLLMLFTVF-------GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM 111

  Fly   349 GYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMA 413
            |||..|..||.||:..|||.|:|||:|:|.|||.||..|...:....:.|.|.....|..|||::
Mouse   112 GYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVIS 176

  Fly   414 MMVSSSITVLGLVNEKNI----MPEPNICVINNRAFFVFGSLV-AFYIPMLMMVTTYALTIPLLR 473
            .::  |...|..:.:|..    .|....|.||::.::|..|.: :|:.|.|:|:..|.....:.:
Mouse   177 AVI--SFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAK 239

  Fly   474 KKARFAAEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEG 538
            ::.|.    |.|   ||                       |.:......|..:|..|       |
Mouse   240 RRTRV----PPS---RR-----------------------GPDACSAPPGGADRRPN-------G 267

  Fly   539 GAPSRRSGVEPAE-RPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGI 602
            ..|.|.:|...|| .||..|                :||..|.........|.|..         
Mouse   268 LGPERGAGPTGAEAEPLPTQ----------------LNGAPGEPAPAGPRDGDALD--------- 307

  Fly   603 FRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNR--RASVRVTIS 665
            ...||||                  :|...|               |....|:|  ||..:...|
Mouse   308 LEESSSS------------------EHAERP---------------PGPRRPDRGPRAKGKTRAS 339

  Fly   666 QPQLGYPTNVGGNGGRTVGATEVGAG---GNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAA 727
            |.:.|......|.|....||:..|.|   |.|:.|.|.                           
Mouse   340 QVKPGDSLPRRGPGAAGPGASGSGHGEERGGGAKASRW--------------------------- 377

  Fly   728 GGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKAT 792
                                                          |.::|        .|::.|
Mouse   378 ----------------------------------------------RGRQN--------REKRFT 388

  Fly   793 KVLGLVFFTFVLCWSPFFI-LNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRA 856
            .||.:|...||:||.|||. ..:|...||   ||..:.|...|.||.:|::||:||||||..||.
Mouse   389 FVLAVVIGVFVVCWFPFFFTYTLIAVGCP---VPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRR 450

  Fly   857 AFIRLL 862
            ||.::|
Mouse   451 AFKKIL 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 63/179 (35%)
TM helix 2 321..343 CDD:410628 12/21 (57%)
TM helix 3 359..381 CDD:410628 12/21 (57%)
TM helix 4 404..420 CDD:410628 4/15 (27%)
TM helix 5 443..466 CDD:410628 6/23 (26%)
7tm_GPCRs <779..858 CDD:475119 32/79 (41%)
TM helix 6 792..814 CDD:410628 11/22 (50%)
TM helix 7 826..851 CDD:410628 11/24 (46%)
Adra2aNP_031443.4 7tmA_alpha2A_AR 49..452 CDD:320445 149/594 (25%)
TM helix 1 50..76 CDD:320445 11/36 (31%)
TM helix 2 83..109 CDD:320445 12/25 (48%)
TM helix 3 121..151 CDD:320445 17/29 (59%)
TM helix 4 163..186 CDD:320445 7/24 (29%)
TM helix 5 208..237 CDD:320445 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..378 47/303 (16%)
TM helix 6 382..412 CDD:320445 13/37 (35%)
TM helix 7 420..445 CDD:320445 11/24 (46%)

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