DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and adra1d

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:XP_002935531.2 Gene:adra1d / 100495969 XenbaseID:XB-GENE-6050827 Length:500 Species:Xenopus tropicalis


Alignment Length:625 Identity:138/625 - (22%)
Similarity:213/625 - (34%) Gaps:280/625 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 LFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWP 352
            |.:|::|.|    :|||:|.|:||.:|:||.|||||:.:|||||||:|..|:|..|....||:|.
 Frog    49 LAVFILFAI----VGNIMVILSVACNRQLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWA 109

  Fly   353 LGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVS 417
            .|..:|:|:...|||.|::||:.:|.||:.||:|::..|......|::...:.:.::|:.:|::|
 Frog   110 FGRVFCDIWAAVDVLCCTASIMSLCVISIDRYVGVKYSLKYPTIMTEKKAVVILILLWLSSMVIS 174

  Fly   418 SSITVLGLVNEKNIMPEPNICVINNR-AFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAE 481
            .. .:||.  ::...|:.:.|.|... .:.:|.||.:||:|:|:::..|                
 Frog   175 IG-PLLGW--KEPPPPDDSKCSITEEPGYALFSSLFSFYLPLLVILVMY---------------- 220

  Fly   482 HPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSG 546
                  ||..                                                       
 Frog   221 ------FRVY------------------------------------------------------- 224

  Fly   547 VEPAERPLMQQRTASSRSMGTVSFRN----VVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSS 607
                   ::.:||..|...|....||    ||                                 
 Frog   225 -------IVARRTTKSLEAGVKKERNKSMEVV--------------------------------- 249

  Fly   608 SSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYP 672
                                           |.||.| |::..||...|                
 Frog   250 -------------------------------LRIHCR-SVLEESSSSTR---------------- 266

  Fly   673 TNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVK 737
                                  :..|.|..|||                                
 Frog   267 ----------------------NHKGHTFRSSL-------------------------------- 277

  Fly   738 PTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTF 802
                        .||..||                             :.|:||.|.|.:|...|
 Frog   278 ------------SVRLLKF-----------------------------SREKKAAKTLAIVVGVF 301

  Fly   803 VLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCK 867
            :|||.|||::..:.:..|..:..:.|.....||||.:|.:|||||...::.|:.||||:|||.|:
 Frog   302 ILCWLPFFLILPLGSFFPALKPTDSVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAFIRILKCQCR 366

  Fly   868 RSGRPL--------RYRSVTEGRGALSLCAPSALPLAISF 899
            |..||:        |....:.|||:.....|:..|:..||
 Frog   367 RRRRPIWRVYDHQWRTSMTSSGRGSDGEHHPNFTPINSSF 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 62/175 (35%)
TM helix 2 321..343 CDD:410628 13/21 (62%)
TM helix 3 359..381 CDD:410628 9/21 (43%)
TM helix 4 404..420 CDD:410628 3/15 (20%)
TM helix 5 443..466 CDD:410628 7/23 (30%)
7tm_GPCRs <779..858 CDD:475119 26/78 (33%)
TM helix 6 792..814 CDD:410628 10/21 (48%)
TM helix 7 826..851 CDD:410628 11/24 (46%)
adra1dXP_002935531.2 7tmA_alpha1D_AR 43..357 CDD:320450 119/574 (21%)
TM helix 1 44..70 CDD:320450 11/24 (46%)
TM helix 2 77..103 CDD:320450 15/25 (60%)
TM helix 3 115..145 CDD:320450 14/29 (48%)
TM helix 4 157..180 CDD:320450 3/23 (13%)
TM helix 5 197..226 CDD:320450 10/112 (9%)
TM helix 6 285..315 CDD:320450 13/29 (45%)
TM helix 7 325..350 CDD:320450 11/24 (46%)

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