DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and htr7

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:XP_031762460.1 Gene:htr7 / 100494876 XenbaseID:XB-GENE-1013674 Length:440 Species:Xenopus tropicalis


Alignment Length:667 Identity:141/667 - (21%)
Similarity:210/667 - (31%) Gaps:295/667 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 SLDMFLPN-LTALNTTSTASTADMATEFAVTKSFLDYSPHGY-------DFLFLFVVFFIFAGGL 301
            |.|..||. |....|.|..||:..::|.......|....:|:       ..|.|..:..|    .
 Frog    34 SFDPRLPKILQDATTASPISTSTFSSENDTQCGELMILNYGHIEKLVIGAILSLITLLTI----A 94

  Fly   302 GNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFL-GYWPLGFTWCNIYVTCD 365
            ||.||.::|...:||:..:||.:.|||:|||.|::.|||..::...: |.|..|..:||:::..|
 Frog    95 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAIAVMPFVSVTDLIGGEWIFGHVFCNVFIAMD 159

  Fly   366 VLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKN 430
            |:.|::||:.:|.||:.||:||..||....|...|.....|..||    ::|:|||:..|.....
 Frog   160 VMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGRCMAKMILCVW----LLSASITLPPLFGWAQ 220

  Fly   431 IMPEPNICVIN-NRAFFVFGSLVAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGR 494
            .:.:..:|:|: :..:.::.:.|||||||.:|:..|   ..:.:...|.||:|           :
 Frog   221 NVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMY---YRIFKAAKRSAAKH-----------K 271

  Fly   495 FT--LRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQ 557
            ||  .||:.|:                 .|...|.|..|..|.||                    
 Frog   272 FTGLPRPEESE-----------------GMISANGNVKTHKESEE-------------------- 299

  Fly   558 RTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRS 622
                                                                    |        
 Frog   300 --------------------------------------------------------C-------- 300

  Fly   623 SSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATE 687
                                                                             
 Frog   301 ----------------------------------------------------------------- 300

  Fly   688 VGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVR 752
                                |:|.|:.                                      
 Frog   301 --------------------TNLSKLL-------------------------------------- 307

  Fly   753 PFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNII-- 815
                                 |:.|.::|  ....||||...||::...|.:||.|||:|:..  
 Frog   308 ---------------------RNDRKNIS--IFKREQKAATTLGIIVGAFTICWLPFFLLSTARP 349

  Fly   816 FAACPECQ-VPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRLLKCNCKRSGRPLRYRSVT 879
            |....||. :|..:..|.|||||.:|.|||.||..|||..|..:..||:|         |||::.
 Frog   350 FICGTECSCIPLWLERTFLWLGYANSLINPFIYAFFNRDLRTTYRNLLQC---------RYRNIN 405

  Fly   880 EGRGALSLCAPSALPLA 896
            ....|..:  ..||.||
 Frog   406 RKLSAAGM--HEALKLA 420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 59/176 (34%)
TM helix 2 321..343 CDD:410628 12/21 (57%)
TM helix 3 359..381 CDD:410628 8/21 (38%)
TM helix 4 404..420 CDD:410628 4/15 (27%)
TM helix 5 443..466 CDD:410628 8/22 (36%)
7tm_GPCRs <779..858 CDD:475119 34/81 (42%)
TM helix 6 792..814 CDD:410628 9/21 (43%)
TM helix 7 826..851 CDD:410628 12/24 (50%)
htr7XP_031762460.1 7tmA_5-HT7 80..393 CDD:320452 118/581 (20%)
TM helix 1 80..106 CDD:320452 8/29 (28%)
TM helix 2 113..139 CDD:320452 12/25 (48%)
TM helix 3 152..182 CDD:320452 13/29 (45%)
TM helix 4 194..216 CDD:320452 8/25 (32%)
TM helix 5 233..262 CDD:320452 9/31 (29%)
TM helix 6 318..348 CDD:320452 13/29 (45%)
TM helix 7 361..386 CDD:320452 12/24 (50%)

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