DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and LOC100488258

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:XP_012818683.1 Gene:LOC100488258 / 100488258 XenbaseID:XB-GENE-29079119 Length:333 Species:Xenopus tropicalis


Alignment Length:619 Identity:105/619 - (16%)
Similarity:173/619 - (27%) Gaps:311/619 - (50%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 DMATEFAVTKSFL--DYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLA 328
            |:..:| |..|.|  :.:|..|..:|:.:...|....:||:||.::::..|:|...||:.:.|||
 Frog     2 DLCFDF-VNNSCLRTNRAPANYSVMFIAMFGAIILTTVGNLLVIISISHFRQLHYPTNFLILSLA 65

  Fly   329 IADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGS 393
            .||.|:.|.|||...:.:....|..|..:|.::...|:..|:.||.|:.|||:.||..:.:||..
 Frog    66 TADFLIGLVVMPYSMVRSLTSCWYFGDLFCKVHSCLDMTLCTGSIYHLFFISVDRYYAVCHPLHY 130

  Fly   394 RHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMP--EPNICVIN-----NRAFFVFGSL 451
            ....|..:..:.:...|.::.:.|..: |...|:.:.|..  ....|:.:     |:.:....||
 Frog   131 YKNLTTNVIELFLLTTWSVSCVFSFGL-VFSNVHTEGIQDYITSYYCIGSCSLTLNKLWGTISSL 194

  Fly   452 VAFYIPMLMMVTTYALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSN 516
            :.|:||..:|:                                                      
 Frog   195 ICFFIPGALMI------------------------------------------------------ 205

  Fly   517 NKFLSMGDGNRNFNTEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAA 581
                                                                             
 Frog   206 ----------------------------------------------------------------- 205

  Fly   582 GSGRRTTGTAHSSFRFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLS 646
                               ||:.|                                         
 Frog   206 -------------------GIYMH----------------------------------------- 210

  Fly   647 LVPPSSHPNRRASVRVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLM 711
                                                                           :.
 Frog   211 ---------------------------------------------------------------IF 212

  Fly   712 KIATIQGPILNQSQAAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSK 776
            .:|.      ||::....:|..|           |.::|                          
 Frog   213 SVAR------NQAKLVHNHHSFQ-----------PDKSK-------------------------- 234

  Fly   777 RNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNII-----FAACPECQVPEHVVNTCLWLG 836
                |..:|..|:||.|.|.:|...|:.||.|||||.:|     |:      |||.:.|..||||
 Frog   235 ----SKISVRAERKAAKTLSIVMGVFLFCWLPFFILTVIDPYINFS------VPEDLYNVFLWLG 289

  Fly   837 YVSSTINPIIYTIFNRTFRAAFIRLLKCNCKRSG 870
            |.:|.:|||||.:|...|:.||..::..|..::|
 Frog   290 YFNSALNPIIYALFYPWFQKAFACIISGNILKAG 323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 47/181 (26%)
TM helix 2 321..343 CDD:410628 11/21 (52%)
TM helix 3 359..381 CDD:410628 7/21 (33%)
TM helix 4 404..420 CDD:410628 2/15 (13%)
TM helix 5 443..466 CDD:410628 6/22 (27%)
7tm_GPCRs <779..858 CDD:475119 35/83 (42%)
TM helix 6 792..814 CDD:410628 11/21 (52%)
TM helix 7 826..851 CDD:410628 13/24 (54%)
LOC100488258XP_012818683.1 7tmA_TAAR2_3_4 23..311 CDD:320437 94/583 (16%)
TM helix 1 24..50 CDD:320437 6/25 (24%)
TM helix 2 57..83 CDD:320437 12/25 (48%)
TM helix 3 95..125 CDD:320437 11/29 (38%)
TM helix 4 137..160 CDD:320437 3/23 (13%)
TM helix 5 185..214 CDD:320437 10/270 (4%)
TM helix 6 240..270 CDD:320437 14/29 (48%)
TM helix 7 279..304 CDD:320437 13/24 (54%)

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